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A4XKG9

- SYL_CALS8

UniProt

A4XKG9 - SYL_CALS8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei581 – 5811ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSAC351627:GJ17-1858-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Csac_1819
    OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
    Taxonomic identifieri351627 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000000256: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817Leucine--tRNA ligasePRO_1000009315Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351627.Csac_1819.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XKG9.
    SMRiA4XKG9. Positions 2-752.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi578 – 5825"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4XKG9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFREIEK KWQQKWFSQN KYKVTEDSPK PKYYVLEMFP YPSGKLHMGH    50
    VRNYSIGDVF ARFMRLKGYN VLHPMGWDAF GLPAENAAIK HGIHPSDWTW 100
    SNIENMKRQL KELGISYDWD REVATCHPDY YKWTQWMFLQ FYKAGLAYRK 150
    RSYVNWCPSC ETVLANEQVV NGRCERCKSL VGKKDLEQWF FRITKYAERL 200
    LRDIDKLDGW PEKVKIMQKN WIGRSEGAEI EFEIDGLGKR IKVFTTRPDT 250
    LFGVTYLVLA PEHPLTKEII AGKPQEKECL EFIEKMQYLN EIERTSTETE 300
    KEGRFTGGYA IHPLTGKKVP IYIANYVLVD YGTGAVMGVP AHDQRDFEFA 350
    KKYNLPIKVV IKGDGVDIQN LQSAYEGEGV LINSGEFNGL KNTEAMKKIT 400
    EYLEKNGYGK ACVTYKLRDW LISRQRYWGA PIPIVYCDDC GIVPVPEEEL 450
    PVLLPYNVEF KPTGQSPLAY CEEFVNTTCP KCGKPARRET DTMDTFICSS 500
    WYYFRYTDPK NSEKPFEKSL VDYWLPVDQY IGGVEHAILH LLYSRFFTKV 550
    LYDLGYISFE EPFKNLLTQG MVLKDGAKMS KSLGNIVSPE EIVEKYGADT 600
    ARLFILFAAP PERDLEWSDQ GVEGCFRFLN RLWRLYIELK DKLSDSSLPG 650
    QSELDDELNY RLNYTIKKVT EDIGERFNFN TAISSIMELL NFLYDYKEKG 700
    SLNRELILKT LKNFLILIYP FTPHIACELW EIMGFEGDIE DVSWPEYDES 750
    ALVRKNVEIA VQINGKVRAR FDVPVDISEE ELKQKIMNNE KIKTLLEGKE 800
    IVKFIYVKNR LVNIVIK 817
    Length:817
    Mass (Da):95,200
    Last modified:May 29, 2007 - v1
    Checksum:i01C44C1BC39859F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP67404.1.
    RefSeqiYP_001180595.1. NC_009437.1.

    Genome annotation databases

    EnsemblBacteriaiABP67404; ABP67404; Csac_1819.
    GeneIDi5086638.
    KEGGicsc:Csac_1819.
    PATRICi21253376. VBICalSac56748_1994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP67404.1 .
    RefSeqi YP_001180595.1. NC_009437.1.

    3D structure databases

    ProteinModelPortali A4XKG9.
    SMRi A4XKG9. Positions 2-752.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351627.Csac_1819.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP67404 ; ABP67404 ; Csac_1819 .
    GeneIDi 5086638.
    KEGGi csc:Csac_1819.
    PATRICi 21253376. VBICalSac56748_1994.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CSAC351627:GJ17-1858-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43494 / DSM 8903.

    Entry informationi

    Entry nameiSYL_CALS8
    AccessioniPrimary (citable) accession number: A4XKG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3