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A4XKG9

- SYL_CALS8

UniProt

A4XKG9 - SYL_CALS8

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Protein
Leucine--tRNA ligase
Gene
leuS, Csac_1819
Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei581 – 5811ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-1858-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Csac_1819
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Leucine--tRNA ligaseUniRule annotation
PRO_1000009315Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1819.

Structurei

3D structure databases

ProteinModelPortaliA4XKG9.
SMRiA4XKG9. Positions 2-752.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotation
Add
BLAST
Motifi578 – 5825"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XKG9-1 [UniParc]FASTAAdd to Basket

« Hide

MEYNFREIEK KWQQKWFSQN KYKVTEDSPK PKYYVLEMFP YPSGKLHMGH    50
VRNYSIGDVF ARFMRLKGYN VLHPMGWDAF GLPAENAAIK HGIHPSDWTW 100
SNIENMKRQL KELGISYDWD REVATCHPDY YKWTQWMFLQ FYKAGLAYRK 150
RSYVNWCPSC ETVLANEQVV NGRCERCKSL VGKKDLEQWF FRITKYAERL 200
LRDIDKLDGW PEKVKIMQKN WIGRSEGAEI EFEIDGLGKR IKVFTTRPDT 250
LFGVTYLVLA PEHPLTKEII AGKPQEKECL EFIEKMQYLN EIERTSTETE 300
KEGRFTGGYA IHPLTGKKVP IYIANYVLVD YGTGAVMGVP AHDQRDFEFA 350
KKYNLPIKVV IKGDGVDIQN LQSAYEGEGV LINSGEFNGL KNTEAMKKIT 400
EYLEKNGYGK ACVTYKLRDW LISRQRYWGA PIPIVYCDDC GIVPVPEEEL 450
PVLLPYNVEF KPTGQSPLAY CEEFVNTTCP KCGKPARRET DTMDTFICSS 500
WYYFRYTDPK NSEKPFEKSL VDYWLPVDQY IGGVEHAILH LLYSRFFTKV 550
LYDLGYISFE EPFKNLLTQG MVLKDGAKMS KSLGNIVSPE EIVEKYGADT 600
ARLFILFAAP PERDLEWSDQ GVEGCFRFLN RLWRLYIELK DKLSDSSLPG 650
QSELDDELNY RLNYTIKKVT EDIGERFNFN TAISSIMELL NFLYDYKEKG 700
SLNRELILKT LKNFLILIYP FTPHIACELW EIMGFEGDIE DVSWPEYDES 750
ALVRKNVEIA VQINGKVRAR FDVPVDISEE ELKQKIMNNE KIKTLLEGKE 800
IVKFIYVKNR LVNIVIK 817
Length:817
Mass (Da):95,200
Last modified:May 29, 2007 - v1
Checksum:i01C44C1BC39859F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67404.1.
RefSeqiYP_001180595.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67404; ABP67404; Csac_1819.
GeneIDi5086638.
KEGGicsc:Csac_1819.
PATRICi21253376. VBICalSac56748_1994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67404.1 .
RefSeqi YP_001180595.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XKG9.
SMRi A4XKG9. Positions 2-752.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP67404 ; ABP67404 ; Csac_1819 .
GeneIDi 5086638.
KEGGi csc:Csac_1819.
PATRICi 21253376. VBICalSac56748_1994.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSAC351627:GJ17-1858-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiSYL_CALS8
AccessioniPrimary (citable) accession number: A4XKG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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