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A4XKG9

- SYL_CALS8

UniProt

A4XKG9 - SYL_CALS8

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei581 – 5811ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-1858-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Csac_1819
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Leucine--tRNA ligasePRO_1000009315Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1819.

Structurei

3D structure databases

ProteinModelPortaliA4XKG9.
SMRiA4XKG9. Positions 2-752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi578 – 5825"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XKG9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYNFREIEK KWQQKWFSQN KYKVTEDSPK PKYYVLEMFP YPSGKLHMGH
60 70 80 90 100
VRNYSIGDVF ARFMRLKGYN VLHPMGWDAF GLPAENAAIK HGIHPSDWTW
110 120 130 140 150
SNIENMKRQL KELGISYDWD REVATCHPDY YKWTQWMFLQ FYKAGLAYRK
160 170 180 190 200
RSYVNWCPSC ETVLANEQVV NGRCERCKSL VGKKDLEQWF FRITKYAERL
210 220 230 240 250
LRDIDKLDGW PEKVKIMQKN WIGRSEGAEI EFEIDGLGKR IKVFTTRPDT
260 270 280 290 300
LFGVTYLVLA PEHPLTKEII AGKPQEKECL EFIEKMQYLN EIERTSTETE
310 320 330 340 350
KEGRFTGGYA IHPLTGKKVP IYIANYVLVD YGTGAVMGVP AHDQRDFEFA
360 370 380 390 400
KKYNLPIKVV IKGDGVDIQN LQSAYEGEGV LINSGEFNGL KNTEAMKKIT
410 420 430 440 450
EYLEKNGYGK ACVTYKLRDW LISRQRYWGA PIPIVYCDDC GIVPVPEEEL
460 470 480 490 500
PVLLPYNVEF KPTGQSPLAY CEEFVNTTCP KCGKPARRET DTMDTFICSS
510 520 530 540 550
WYYFRYTDPK NSEKPFEKSL VDYWLPVDQY IGGVEHAILH LLYSRFFTKV
560 570 580 590 600
LYDLGYISFE EPFKNLLTQG MVLKDGAKMS KSLGNIVSPE EIVEKYGADT
610 620 630 640 650
ARLFILFAAP PERDLEWSDQ GVEGCFRFLN RLWRLYIELK DKLSDSSLPG
660 670 680 690 700
QSELDDELNY RLNYTIKKVT EDIGERFNFN TAISSIMELL NFLYDYKEKG
710 720 730 740 750
SLNRELILKT LKNFLILIYP FTPHIACELW EIMGFEGDIE DVSWPEYDES
760 770 780 790 800
ALVRKNVEIA VQINGKVRAR FDVPVDISEE ELKQKIMNNE KIKTLLEGKE
810
IVKFIYVKNR LVNIVIK
Length:817
Mass (Da):95,200
Last modified:May 29, 2007 - v1
Checksum:i01C44C1BC39859F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA. Translation: ABP67404.1.
RefSeqiYP_001180595.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67404; ABP67404; Csac_1819.
GeneIDi5086638.
KEGGicsc:Csac_1819.
PATRICi21253376. VBICalSac56748_1994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA. Translation: ABP67404.1 .
RefSeqi YP_001180595.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XKG9.
SMRi A4XKG9. Positions 2-752.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP67404 ; ABP67404 ; Csac_1819 .
GeneIDi 5086638.
KEGGi csc:Csac_1819.
PATRICi 21253376. VBICalSac56748_1994.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSAC351627:GJ17-1858-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiSYL_CALS8
AccessioniPrimary (citable) accession number: A4XKG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3