A4XK08 (A4XK08_CALS8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL ABP67243.1
EC=4.2.1.24 EMBL ABP67243.1

Gene names

Ordered Locus Names:

Csac_1653

Organism

Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [Complete proteome] [HAMAP]

Taxonomic identifier

351627 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL ABP67243.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	193	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	246	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	118	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	128	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	231	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	203	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	215	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	272	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	311	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A4XK08 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: CD2ED51D6F396EEB	FASTA	325	36,343
	10 20 30 40 50 60 MEFKRLRRLR QSKALRELFY ETRLYSKEFI FPLFVDDGKN VFERMPQLDG IVKVSVDRLH 70 80 90 100 110 120 EILDEIKKVD IGGVILFGVT SQKDEMGSYA TKDDGAVQQA IRKIKEYSED ILVFADVCLC 130 140 150 160 170 180 EYTSHGHCGI LQGDKIDNDK TIEVLSEIAL SYAKAGADII CPSDMMDGRV DAIRKKLDSH 190 200 210 220 230 240 GFVYTPIIPY SAKFASSLYA PFRDVANSRP AFGDRKSYQM PYQNKREALR EIEADILEGA 250 260 270 280 290 300 DAVIIKPALT SLDVISAAKE KFNIPIIAYN VSGEYAMVKS AGKLGLLNEE EVIIEILTAI 310 320 KRAGADAIIT YHALEAARIL NGKEL

References

[1]

"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43494 / DSM 8903.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000679 Genomic DNA. Translation: ABP67243.1.
RefSeq	YP_001180434.1. NC_009437.1.
3D structure databases
ProteinModelPortal	A4XK08.
ModBase	Search...
Protein-protein interaction databases
STRING	A4XK08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5088972.
GenomeReviews	Gene locus Csac_1653 in contig CP000679_GR.
KEGG	csc:Csac_1653.
PATRIC	21253022. VBICalSac56748_1820.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	TEAYNEN.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4XK08_CALS8

Accession

Primary (citable) accession number: A4XK08

Entry history

Integrated into UniProtKB/TrEMBL:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)