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A4XJY4

- A4XJY4_CALS8

UniProt

A4XJY4 - A4XJY4_CALS8

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

Csac_1629

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: InterPro
  3. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-1667-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Ordered Locus Names:Csac_1629Imported
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)Imported
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351627.Csac_1629.

Structurei

3D structure databases

ProteinModelPortaliA4XJY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034028.
KOiK01589.
OMAiDCILEGW.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XJY4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKGVFGYPL MKIGIIGGGQ LGKMLSQKAK QMGFYVISLD PSAACPAASV
60 70 80 90 100
SDELIVSDFY SPEKLKELVE KSDITTYEIE HINTSVLKEL YDEGYNILPS
110 120 130 140 150
PYCLEIIQDK LKQKQVLQSA GLPVPRFERV ESFDISFFEN FGFPLVQKAT
160 170 180 190 200
KGGYDGRGVV VLKSKDDINK VLKTESYIEE FVDVEKELAV IVARNKKGDV
210 220 230 240 250
VSYPVVEMVF DETANILDIL IVPARVEKDI EDEAKKIAIK AVEALQGVGV
260 270 280 290 300
FGVELFLTKD RKILINEIAP RPHNSGHYTI EACITSQFEQ HLRAICDLPL
310 320 330 340 350
GSTKLLSPAV MINLLGDDGY KGTPVIEGLI DALSIEGVSF HFYGKKVTAP
360 370 380
FRKMGHVTIL DDNLERAIEK AKKVKEVLKI KSEV
Length:384
Mass (Da):42,589
Last modified:May 29, 2007 - v1
Checksum:iCC1F140EE4EECC9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67219.1.
RefSeqiWP_011917154.1. NC_009437.1.
YP_001180410.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67219; ABP67219; Csac_1629.
GeneIDi5087108.
KEGGicsc:Csac_1629.
PATRICi21252974. VBICalSac56748_1796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67219.1 .
RefSeqi WP_011917154.1. NC_009437.1.
YP_001180410.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XJY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP67219 ; ABP67219 ; Csac_1629 .
GeneIDi 5087108.
KEGGi csc:Csac_1629.
PATRICi 21252974. VBICalSac56748_1796.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034028.
KOi K01589.
OMAi DCILEGW.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci CSAC351627:GJ17-1667-MONOMER.

Family and domain databases

Gene3Di 3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903Imported.

Entry informationi

Entry nameiA4XJY4_CALS8
AccessioniPrimary (citable) accession number: A4XJY4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3