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A4XJN8

- ARGB_CALS8

UniProt

A4XJN8 - ARGB_CALS8

Protein

Acetylglutamate kinase

Gene

argB

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei33 – 331Transition state stabilizerUniRule annotation
    Binding sitei90 – 901SubstrateUniRule annotation
    Binding sitei189 – 1891SubstrateUniRule annotation
    Sitei251 – 2511Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. acetylglutamate kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. glutamate 5-kinase activity Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-UniPathway
    2. proline biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSAC351627:GJ17-1567-MONOMER.
    UniPathwayiUPA00068; UER00107.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
    Alternative name(s):
    N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
    NAG kinaseUniRule annotation
    Short name:
    AGKUniRule annotation
    Gene namesi
    Name:argBUniRule annotation
    Ordered Locus Names:Csac_1530
    OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
    Taxonomic identifieri351627 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000000256: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293Acetylglutamate kinasePRO_0000335616Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351627.Csac_1530.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XJN8.
    SMRiA4XJN8. Positions 9-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 692Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the acetylglutamate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0548.
    HOGENOMiHOG000233259.
    KOiK00930.
    OMAiPGVLDKN.
    OrthoDBiEOG6T1WVF.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00082_A. ArgB_A.
    MF_00082_B. ArgB_B.
    InterProiIPR004662. AcgluKinase.
    IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000728. NAGK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR00761. argB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XJN8-1 [UniParc]FASTAAdd to Basket

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    MYEEMDKLIE KASILIEALP YIQKLYGKTV VIKYGGNAMI NDKLKNWVME    50
    DITLLKYIGV NPIVVHGGGP EINSVLKKLN VESQFVNGLR VTDMQTMEVA 100
    QMVLVGKTNK ELVSMLNQKG GKAIGICGID GNLIQARKHY EIVNGEKVDL 150
    GYVGEVVSIN AKVLEMLAKD EYIPVVAPIG VGEDGTSYNI NADTVAAEIA 200
    KAIKAEKLMF MTDVEGLKYD KNSSEIISAI SADEVLKMID EGKIDGGMIP 250
    KVLGCIDALK HGVNRTHILD GRIPHCILLE IFTDKGIGTM IHL 293
    Length:293
    Mass (Da):32,014
    Last modified:May 29, 2007 - v1
    Checksum:iF862454708B87149
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP67123.1.
    RefSeqiYP_001180314.1. NC_009437.1.

    Genome annotation databases

    EnsemblBacteriaiABP67123; ABP67123; Csac_1530.
    GeneIDi5088112.
    KEGGicsc:Csac_1530.
    PATRICi21252756. VBICalSac56748_1688.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP67123.1 .
    RefSeqi YP_001180314.1. NC_009437.1.

    3D structure databases

    ProteinModelPortali A4XJN8.
    SMRi A4XJN8. Positions 9-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351627.Csac_1530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP67123 ; ABP67123 ; Csac_1530 .
    GeneIDi 5088112.
    KEGGi csc:Csac_1530.
    PATRICi 21252756. VBICalSac56748_1688.

    Phylogenomic databases

    eggNOGi COG0548.
    HOGENOMi HOG000233259.
    KOi K00930.
    OMAi PGVLDKN.
    OrthoDBi EOG6T1WVF.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00107 .
    BioCyci CSAC351627:GJ17-1567-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00082_A. ArgB_A.
    MF_00082_B. ArgB_B.
    InterProi IPR004662. AcgluKinase.
    IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000728. NAGK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR00761. argB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43494 / DSM 8903.

    Entry informationi

    Entry nameiARGB_CALS8
    AccessioniPrimary (citable) accession number: A4XJN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3