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A4XJN8

- ARGB_CALS8

UniProt

A4XJN8 - ARGB_CALS8

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Protein
Acetylglutamate kinase
Gene
argB, Csac_1530
Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei33 – 331Transition state stabilizer By similarity
Binding sitei90 – 901Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Sitei251 – 2511Transition state stabilizer By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. acetylglutamate kinase activity Source: UniProtKB-HAMAP
  3. glutamate 5-kinase activity Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. proline biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-1567-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinase (EC:2.7.2.8)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name:
AGK
Gene namesi
Name:argB
Ordered Locus Names:Csac_1530
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Acetylglutamate kinaseUniRule annotation
PRO_0000335616Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1530.

Structurei

3D structure databases

ProteinModelPortaliA4XJN8.
SMRiA4XJN8. Positions 9-292.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 692Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK00930.
OMAiPGVLDKN.
OrthoDBiEOG6T1WVF.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_A. ArgB_A.
MF_00082_B. ArgB_B.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XJN8-1 [UniParc]FASTAAdd to Basket

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MYEEMDKLIE KASILIEALP YIQKLYGKTV VIKYGGNAMI NDKLKNWVME    50
DITLLKYIGV NPIVVHGGGP EINSVLKKLN VESQFVNGLR VTDMQTMEVA 100
QMVLVGKTNK ELVSMLNQKG GKAIGICGID GNLIQARKHY EIVNGEKVDL 150
GYVGEVVSIN AKVLEMLAKD EYIPVVAPIG VGEDGTSYNI NADTVAAEIA 200
KAIKAEKLMF MTDVEGLKYD KNSSEIISAI SADEVLKMID EGKIDGGMIP 250
KVLGCIDALK HGVNRTHILD GRIPHCILLE IFTDKGIGTM IHL 293
Length:293
Mass (Da):32,014
Last modified:May 29, 2007 - v1
Checksum:iF862454708B87149
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67123.1.
RefSeqiYP_001180314.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67123; ABP67123; Csac_1530.
GeneIDi5088112.
KEGGicsc:Csac_1530.
PATRICi21252756. VBICalSac56748_1688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67123.1 .
RefSeqi YP_001180314.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XJN8.
SMRi A4XJN8. Positions 9-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP67123 ; ABP67123 ; Csac_1530 .
GeneIDi 5088112.
KEGGi csc:Csac_1530.
PATRICi 21252756. VBICalSac56748_1688.

Phylogenomic databases

eggNOGi COG0548.
HOGENOMi HOG000233259.
KOi K00930.
OMAi PGVLDKN.
OrthoDBi EOG6T1WVF.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00107 .
BioCyci CSAC351627:GJ17-1567-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00082_A. ArgB_A.
MF_00082_B. ArgB_B.
InterProi IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000728. NAGK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR00761. argB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiARGB_CALS8
AccessioniPrimary (citable) accession number: A4XJN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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