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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCSAC351627:G1G8P-1412-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:Csac_1364
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000000256 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003407621 – 1403-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST140

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1364

Structurei

3D structure databases

ProteinModelPortaliA4XJ81
SMRiA4XJ81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN Bacteria
COG0764 LUCA
HOGENOMiHOG000277829
KOiK02372
OMAiGIDECRF
OrthoDBiPOG091H005Q

Family and domain databases

HAMAPiMF_00406 FabZ, 1 hit
InterProiView protein in InterPro
IPR013114 FabA_FabZ
IPR010084 FabZ
IPR029069 HotDog_dom_sf
PfamiView protein in Pfam
PF07977 FabA, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR01750 fabZ, 1 hit

Sequencei

Sequence statusi: Complete.

A4XJ81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDVTSILQI LPHRYPFLLV DRIIEIEEGK KAKGIKNVTI NEPFFQGHFP
60 70 80 90 100
GNPVMPGVLI VEAMAQVGAV AILSKEEFKG KTPFFAGIDK VRFKKVVRPG
110 120 130 140
DVLLIETELI SLKGYIGKAK ATAYVEGEVV CEGELLFAIK
Length:140
Mass (Da):15,476
Last modified:May 29, 2007 - v1
Checksum:iC4B6760240E35A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA Translation: ABP66966.1
RefSeqiWP_011916902.1, NC_009437.1

Genome annotation databases

EnsemblBacteriaiABP66966; ABP66966; Csac_1364
KEGGicsc:Csac_1364

Similar proteinsi

Entry informationi

Entry nameiFABZ_CALS8
AccessioniPrimary (citable) accession number: A4XJ81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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