Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4XIU2

- FTHS_CALS8

UniProt

A4XIU2 - FTHS_CALS8

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSAC351627:GJ17-1253-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Csac_1224
    OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
    Taxonomic identifieri351627 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000000256: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_0000318565Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351627.Csac_1224.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XIU2.
    SMRiA4XIU2. Positions 7-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XIU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSTSKLQEM KLKNITEIAE SVGLSEDDIE LYGKYKAKIS LDVLKQKPRQ    50
    REGKVILVTS INPTPYGEGK TTTAIGLSMA INRLGFKSIV TLREPSLGPY 100
    LGIKGGATGG GVAQVLPSTD INLHFTGDIH AVTSANNLLC AAIDNHIYHG 150
    NELNINPKAV MVKRAMDMND RALRNIVIGL GDGQRGAVRE DGFIISVASE 200
    VMAILCLSND LEDLKERLGN ILVGFSYDKK PIYAKDLKVH GAMALLLKDA 250
    IKPNLVQTSE ATAAIIHGGP FANIAHGTNS IIAIKIAQKL SDYVVVEAGF 300
    GADLGAEKFV NIVSRKSGIY PSAAVMVVTT KALKYHGSMG AKENLTSENI 350
    DTLKKGFKNL EKHIENLKLL GLEAIVTLNR FPHDTPAEIS EIESFCKERG 400
    VEFAVSEAYE LGSEGALDLA QKVIEVASRK RKINFVYEDS DPVEEKIRKV 450
    AKTIYGAADV QFSKSALLGL ELIKKLNIDH FPICMAKTQY SLSDDPKLLG 500
    RPKDFVLNVN EIRINNGAQF IVVICGDIMT MPGLSKDYAA LHLDIDEDGN 550
    VVWV 554
    Length:554
    Mass (Da):60,246
    Last modified:May 29, 2007 - v1
    Checksum:iCADABD9B733011CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP66827.1.
    RefSeqiWP_011916763.1. NC_009437.1.
    YP_001180018.1. NC_009437.1.

    Genome annotation databases

    EnsemblBacteriaiABP66827; ABP66827; Csac_1224.
    GeneIDi5087440.
    KEGGicsc:Csac_1224.
    PATRICi21252104. VBICalSac56748_1366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP66827.1 .
    RefSeqi WP_011916763.1. NC_009437.1.
    YP_001180018.1. NC_009437.1.

    3D structure databases

    ProteinModelPortali A4XIU2.
    SMRi A4XIU2. Positions 7-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351627.Csac_1224.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP66827 ; ABP66827 ; Csac_1224 .
    GeneIDi 5087440.
    KEGGi csc:Csac_1224.
    PATRICi 21252104. VBICalSac56748_1366.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CSAC351627:GJ17-1253-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43494 / DSM 8903.

    Entry informationi

    Entry nameiFTHS_CALS8
    AccessioniPrimary (citable) accession number: A4XIU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3