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A4XID4 (AROE_CALS8) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:Csac_1055
OrganismCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [Complete proteome] [HAMAP]
Taxonomic identifier351627 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Shikimate dehydrogenase HAMAP MF_00222
PRO_1000021269

Regions

Nucleotide binding127 – 1315NADP By similarity

Sites

Active site671Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
A4XID4 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 2473596A74A01B29

FASTA27931,990
        10         20         30         40         50         60 
MKKLYLIGKS LKHSISPLIH NKILSNFGID AVYSNVELPD FEKLKEFVEM VKKDGDVVGF 

        70         80         90        100        110        120 
NITIPYKEDI LEFCDEVSED VRIIQAANTV KKEGEKLVAY NTDWLGFKRS LEEVGISVKD 

       130        140        150        160        170        180 
KRILILGAGG AAKACIYGLY RMGVKEVFVA NRTYEKAESL KEVFQDILKI LPVEWLRRYE 

       190        200        210        220        230        240 
FKYDIIINTT SVGMFPNIES SPFDFENYVA GIPVFVYDMI YNPPKTTFLE EAEKKGSKTE 

       250        260        270 
NGLKMLVYQA VEAEKIWFDI VNLSQSFLLE ILKECEKKI

« Hide

References

[1]"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43494 / DSM 8903.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000679 Genomic DNA. Translation: ABP66669.1.
RefSeqYP_001179860.1. NC_009437.1.

3D structure databases

ProteinModelPortalA4XID4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4XID4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5088559.
GenomeReviewsGene locus Csac_1055 in contig CP000679_GR.
KEGGcsc:Csac_1055.
PATRIC21251746. VBICalSac56748_1188.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0169.
HOGENOMHBG553408.
OMALKEFVEM.
ProtClustDBCLSK2472922.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_CALS8
AccessionPrimary (citable) accession number: A4XID4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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