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A4XIC0

- A4XIC0_CALS8

UniProt

A4XIC0 - A4XIC0_CALS8

Protein

Alanine racemase

Gene

Csac_1041

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCSAC351627:GJ17-1070-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Csac_1041Imported
    OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)Imported
    Taxonomic identifieri351627 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000000256: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi351627.Csac_1041.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XIC0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4XIC0-1 [UniParc]FASTAAdd to Basket

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    MSLYSRVWAE INLDNLIYNV NNIKEKILPN TQIMAVVKAD AYGHGAIEVS    50
    RVLVRNGINM LAVAIIDEAL QLRHYNFDIP ILILGFTPFE LSEQVVENDI 100
    SQTVYTFEQA YYLNEAAKKI GKKAKVHIKV DTGMGRIGFL CTKESIETII 150
    RIASLSHIEL EGIFSHFSSA DDPQSDNFTY EQFLRFENFV KELNKNGVYF 200
    KYRHIANSAA AIRFPQYQLD IVRLGLVLYG LYPSEAVKTE ISLKPVMSVK 250
    AKVINVKEVP EGYPISYNRK YVTPCKSKIA TIPIGYADGF TRVGSEKRYV 300
    LINGEYAKVV GNVCMDQCMV DVTHIRDVKI GDEVVIIGKQ GKNEITADDL 350
    ASQIGTINYE VICSVSKRIP RVYIRDGRVV KILNYIL 387
    Length:387
    Mass (Da):43,698
    Last modified:May 29, 2007 - v1
    Checksum:i95A6A3F9583FF17B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP66655.1.
    RefSeqiWP_011916602.1. NC_009437.1.
    YP_001179846.1. NC_009437.1.

    Genome annotation databases

    EnsemblBacteriaiABP66655; ABP66655; Csac_1041.
    GeneIDi5089080.
    KEGGicsc:Csac_1041.
    PATRICi21251718. VBICalSac56748_1174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP66655.1 .
    RefSeqi WP_011916602.1. NC_009437.1.
    YP_001179846.1. NC_009437.1.

    3D structure databases

    ProteinModelPortali A4XIC0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351627.Csac_1041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP66655 ; ABP66655 ; Csac_1041 .
    GeneIDi 5089080.
    KEGGi csc:Csac_1041.
    PATRICi 21251718. VBICalSac56748_1174.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CSAC351627:GJ17-1070-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43494 / DSM 8903Imported.

    Entry informationi

    Entry nameiA4XIC0_CALS8
    AccessioniPrimary (citable) accession number: A4XIC0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3