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A4XIC0

- A4XIC0_CALS8

UniProt

A4XIC0 - A4XIC0_CALS8

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Protein
Alanine racemase
Gene
Csac_1041
Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei136 – 1361Substrate By similarityUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-1070-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Csac_1041Imported
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)Imported
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1041.

Structurei

3D structure databases

ProteinModelPortaliA4XIC0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XIC0-1 [UniParc]FASTAAdd to Basket

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MSLYSRVWAE INLDNLIYNV NNIKEKILPN TQIMAVVKAD AYGHGAIEVS    50
RVLVRNGINM LAVAIIDEAL QLRHYNFDIP ILILGFTPFE LSEQVVENDI 100
SQTVYTFEQA YYLNEAAKKI GKKAKVHIKV DTGMGRIGFL CTKESIETII 150
RIASLSHIEL EGIFSHFSSA DDPQSDNFTY EQFLRFENFV KELNKNGVYF 200
KYRHIANSAA AIRFPQYQLD IVRLGLVLYG LYPSEAVKTE ISLKPVMSVK 250
AKVINVKEVP EGYPISYNRK YVTPCKSKIA TIPIGYADGF TRVGSEKRYV 300
LINGEYAKVV GNVCMDQCMV DVTHIRDVKI GDEVVIIGKQ GKNEITADDL 350
ASQIGTINYE VICSVSKRIP RVYIRDGRVV KILNYIL 387
Length:387
Mass (Da):43,698
Last modified:May 29, 2007 - v1
Checksum:i95A6A3F9583FF17B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP66655.1.
RefSeqiWP_011916602.1. NC_009437.1.
YP_001179846.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP66655; ABP66655; Csac_1041.
GeneIDi5089080.
KEGGicsc:Csac_1041.
PATRICi21251718. VBICalSac56748_1174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP66655.1 .
RefSeqi WP_011916602.1. NC_009437.1.
YP_001179846.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XIC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP66655 ; ABP66655 ; Csac_1041 .
GeneIDi 5089080.
KEGGi csc:Csac_1041.
PATRICi 21251718. VBICalSac56748_1174.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CSAC351627:GJ17-1070-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiA4XIC0_CALS8
AccessioniPrimary (citable) accession number: A4XIC0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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