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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi117 – 123ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAC351627:G1G8P-965-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:Csac_0923
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000000256 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000568781 – 453UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST453

Proteomic databases

PRIDEiA4XI02

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_0923

Structurei

3D structure databases

ProteinModelPortaliA4XI02
SMRiA4XI02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMZ Bacteria
COG0771 LUCA
HOGENOMiHOG000049428
KOiK01925
OMAiVDKGNDY
OrthoDBiPOG091H002Z

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

A4XI02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFGKKVLV IGMGKSGISS ARFLKKHGAY VVAFDEKRED EMKTQQKETI
60 70 80 90 100
RKFADELYFN DLPDAVVDTS DMVVISPGVP LTKRYITLAH KRGIEVIGEI
110 120 130 140 150
ELAYRFCRSK NIVAITGTNG KTTTTTLVGE ILKKVFDNVI VCGNIGFPFI
160 170 180 190 200
DYVESSTDDT IFVIEISSFQ LETIKYFKPM VGCILNITPD HLNRHMNMDN
210 220 230 240 250
YIRAKMRIFE NIDQEGYSVL NMDNSITRDL IGCAKGTVIT FSKNESDTQN
260 270 280 290 300
SVFVDGDFIY RNFLGKVEKV MRKDDIFMPG EHNLENTLAA IGCVLPFEIQ
310 320 330 340 350
PSIIEKTLKE FKGVEHRIEF VREINGVRFY NDSKGTNTDA SSKALNSFEV
360 370 380 390 400
PIILIAGGYD KGESFEKFAK LISQKVKKVF LLGQTKQKIA DQLQKIGYLN
410 420 430 440 450
FEFVEDLKEA VKKSFEIAKE GDVVLLSPAC ASWDMFESYE QRGRLFKQYV

NEL
Length:453
Mass (Da):51,359
Last modified:May 29, 2007 - v1
Checksum:iDD92A0A801D96303
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA Translation: ABP66537.1
RefSeqiWP_011916483.1, NC_009437.1

Genome annotation databases

EnsemblBacteriaiABP66537; ABP66537; Csac_0923
KEGGicsc:Csac_0923

Similar proteinsi

Entry informationi

Entry nameiMURD_CALS8
AccessioniPrimary (citable) accession number: A4XI02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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