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A4XG24

- GCH4_CALS8

UniProt

A4XG24 - GCH4_CALS8

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1431May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCSAC351627:GJ17-216-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Csac_0211
    OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
    Taxonomic identifieri351627 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000000256: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256GTP cyclohydrolase FolE2PRO_1000068664Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351627.Csac_0211.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XG24.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XG24-1 [UniParc]FASTAAdd to Basket

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    MIDVQSQKDL RGIAIQKVGI KDLNWPIVVM DRANKTQTTI AKITAAAELK    50
    GDMRGTHMSR FIEAIDELNV VGPKEIERLL DRIKEKLDSQ KAYVRFDFPY 100
    FINKRTPVTE TLAPLKVDCY FEAEKGEKFD LKVGVIVPVH TLCPCSKEIS 150
    EYGAHNQRAY VTIEVKMRRF MWIEELVEIA ESSASCPLYS ILKRPDEKWV 200
    TERAYQNPRF VEDLLREVVV KISGDKRIKW YKVFVESIES IHNHNAFAYI 250
    EGENTK 256
    Length:256
    Mass (Da):29,628
    Last modified:May 29, 2007 - v1
    Checksum:i273395F8E8D7267B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP65859.1.
    RefSeqiWP_011915824.1. NC_009437.1.
    YP_001179050.1. NC_009437.1.

    Genome annotation databases

    EnsemblBacteriaiABP65859; ABP65859; Csac_0211.
    GeneIDi5088500.
    KEGGicsc:Csac_0211.
    PATRICi21249822. VBICalSac56748_0250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP65859.1 .
    RefSeqi WP_011915824.1. NC_009437.1.
    YP_001179050.1. NC_009437.1.

    3D structure databases

    ProteinModelPortali A4XG24.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351627.Csac_0211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP65859 ; ABP65859 ; Csac_0211 .
    GeneIDi 5088500.
    KEGGi csc:Csac_0211.
    PATRICi 21249822. VBICalSac56748_0250.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CSAC351627:GJ17-216-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43494 / DSM 8903.

    Entry informationi

    Entry nameiGCH4_CALS8
    AccessioniPrimary (citable) accession number: A4XG24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3