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A4XG24

- GCH4_CALS8

UniProt

A4XG24 - GCH4_CALS8

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1431May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-216-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Csac_0211
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256GTP cyclohydrolase FolE2PRO_1000068664Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_0211.

Structurei

3D structure databases

ProteinModelPortaliA4XG24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XG24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDVQSQKDL RGIAIQKVGI KDLNWPIVVM DRANKTQTTI AKITAAAELK
60 70 80 90 100
GDMRGTHMSR FIEAIDELNV VGPKEIERLL DRIKEKLDSQ KAYVRFDFPY
110 120 130 140 150
FINKRTPVTE TLAPLKVDCY FEAEKGEKFD LKVGVIVPVH TLCPCSKEIS
160 170 180 190 200
EYGAHNQRAY VTIEVKMRRF MWIEELVEIA ESSASCPLYS ILKRPDEKWV
210 220 230 240 250
TERAYQNPRF VEDLLREVVV KISGDKRIKW YKVFVESIES IHNHNAFAYI

EGENTK
Length:256
Mass (Da):29,628
Last modified:May 29, 2007 - v1
Checksum:i273395F8E8D7267B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP65859.1.
RefSeqiYP_001179050.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP65859; ABP65859; Csac_0211.
GeneIDi5088500.
KEGGicsc:Csac_0211.
PATRICi21249822. VBICalSac56748_0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP65859.1 .
RefSeqi YP_001179050.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XG24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_0211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP65859 ; ABP65859 ; Csac_0211 .
GeneIDi 5088500.
KEGGi csc:Csac_0211.
PATRICi 21249822. VBICalSac56748_0250.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CSAC351627:GJ17-216-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiGCH4_CALS8
AccessioniPrimary (citable) accession number: A4XG24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3