Reviewed, UniProtKB/Swiss-Prot A4XFZ6 (COMB_CALS8)

Names and origin

Protein names

Recommended name:
    Probable 2-phosphosulfolactate phosphatase
    EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	Csac_0183

Organism

Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [Complete proteome] [HAMAP]

Taxonomic identifier

351627 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the comB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000081391

Sequences

	Sequence		Length	Mass (Da)
	A4XFZ6-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: EA77B1234BC459C6	FASTA	242	27,481
	10 20 30 40 50 60 MKIITFSHYK EVTDDVLKDS YAVVIDLLRA TSTMIWAISN GAKGIIPVED ISEARLLKRL 70 80 90 100 110 120 DESVLLGGER GGLKIEGFDL DNSPLSYKKE AIFGKTVVMT TTNGTRALKK ASCAKRIFLG 130 140 150 160 170 180 SFINAKKTAE YIMKETLHYN IDTISIVCAG TEEKFTLEDI LCAGYFVDLF IENFPDVFLD 190 200 210 220 230 240 DLSLASHVLY KKFENDPHEI LKYSYHYNHL KKLGFEADLE FCLRKDFVDC VCEFRNLVVE KV

References

[1]

"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000679 Genomic DNA. Translation: ABP65831.1.
RefSeq	YP_001179022.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5089237.
GenomeReviews	Gene locus Csac_0183 in contig CP000679_GR.
KEGG	csc:Csac_0183.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A4XFZ6. DFICSGY.
Family and domain databases
HAMAP	MF_00490. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. [Graphical view]
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COMB_CALS8

Accession

Primary (citable) accession number: A4XFZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 29, 2007
Last modified:	June 16, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)