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Protein

Acetaldehyde dehydrogenase 1

Gene

Saro_3688

Organism
Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Acyl-thioester intermediateUniRule annotation1
Binding sitei288NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciNARO279238:G1G5T-3888-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:Saro_3688
Encoded oniPlasmid pNL20 Publication
OrganismiNovosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
Proteomesi
  • UP000009134 Componenti: Plasmid pNL2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877001 – 311Acetaldehyde dehydrogenase 1Add BLAST311

Proteomic databases

PRIDEiA4XF36

Structurei

3D structure databases

ProteinModelPortaliA4XF36
SMRiA4XF36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149
KOiK04073
OMAiMIKVIRH
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A4XF36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRVKAAIIG SGNIGTDLMM KMIKYPQNME LAIVVGIDEK SEGLAMAREH
60 70 80 90 100
GIATTHEGLE GLRRHPLYKE IGIAFDATSA YAHKVHDEAL RADGIQVVDL
110 120 130 140 150
TPAAIGPFTV PPVNMSQHLD QPNVNMVTCG GQATIPMVAA VARVSDKVHY
160 170 180 190 200
AEIVASVSSR SAGPGTRANI DEFTRTTARA IEVVGGATRG KAIIILNPAE
210 220 230 240 250
PPMIMRDTVF TLSEGADEDQ IRRSVADMVA EVQKYVPGYR LKQEVQFERF
260 270 280 290 300
GDNNKLKIPG QGEFTGIKSM IMLEVEGAGD YLPSYSGNLD IMTAAAKATG
310
ELLAARRMAA A
Length:311
Mass (Da):33,365
Last modified:May 29, 2007 - v1
Checksum:i75D1AD29DD55CCF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000677 Genomic DNA Translation: ABP64547.1
RefSeqiWP_011906931.1, NC_009427.1

Genome annotation databases

EnsemblBacteriaiABP64547; ABP64547; Saro_3688
KEGGinar:Saro_3688

Similar proteinsi

Entry informationi

Entry nameiACDH1_NOVAD
AccessioniPrimary (citable) accession number: A4XF36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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