Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4XF36 (ACDH1_NOVAD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Ordered Locus Names:Saro_3688
Encoded onPlasmid pNL2
OrganismNovosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]
Taxonomic identifier279238 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000387700

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding161 – 1699NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2881NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A4XF36 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 75D1AD29DD55CCF8

FASTA31133,365
        10         20         30         40         50         60 
MTRVKAAIIG SGNIGTDLMM KMIKYPQNME LAIVVGIDEK SEGLAMAREH GIATTHEGLE 

        70         80         90        100        110        120 
GLRRHPLYKE IGIAFDATSA YAHKVHDEAL RADGIQVVDL TPAAIGPFTV PPVNMSQHLD 

       130        140        150        160        170        180 
QPNVNMVTCG GQATIPMVAA VARVSDKVHY AEIVASVSSR SAGPGTRANI DEFTRTTARA 

       190        200        210        220        230        240 
IEVVGGATRG KAIIILNPAE PPMIMRDTVF TLSEGADEDQ IRRSVADMVA EVQKYVPGYR 

       250        260        270        280        290        300 
LKQEVQFERF GDNNKLKIPG QGEFTGIKSM IMLEVEGAGD YLPSYSGNLD IMTAAAKATG 

       310 
ELLAARRMAA A 

« Hide

References

[1]"Complete sequence of plasmid pNL2 of Novosphingobium aromaticivorans DSM 12444."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Han C., Thomson S., Schmutz J., Larimer F., Land M., Kyrpides N. expand/collapse author list , Ivanova N., Fredrickson J., Romine M.F., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 12444.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000677 Genomic DNA. Translation: ABP64547.1.
RefSeqYP_001166073.1. NC_009427.1.

3D structure databases

ProteinModelPortalA4XF36.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279238.Saro_3688.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP64547; ABP64547; Saro_3688.
GeneID5077836.
KEGGnar:Saro_3688.
PATRIC22790514. VBINovAro50627_3907.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAIATTHEG.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycNARO279238:GHBU-3699-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_NOVAD
AccessionPrimary (citable) accession number: A4XF36
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families