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Protein

Acetaldehyde dehydrogenase 2

Gene

Saro_3853

Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
Binding sitei287 – 2871NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADUniRule annotation
Nucleotide bindingi160 – 1689NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNARO279238:GHBU-3864-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Saro_3853
Encoded oniPlasmid pNL10 Publication
OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009134 Componenti: Plasmid pNL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Acetaldehyde dehydrogenase 2PRO_0000387701Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4XDT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiTHIEMGA.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XDT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKMKCAIIG SGNIGTDLMI KLLKGSDTLE LAAVVGIDPA SEGLAMASER
60 70 80 90 100
GVPTTHEGIE GLCRMPQYAD IGIAFDATSA YAHKAHDEIL ARDGKLMVDL
110 120 130 140 150
TPAAIGPATI PPVNPAVDAA VRNINMVTCG GQATIPIVAA VSQVAKVHYA
160 170 180 190 200
EIVASVSSRS AGPGTRANID EFTRTTARAI ETVGGAAKGR AVIILNPAEP
210 220 230 240 250
PMIMRDTIFT LSEMVDEDKV RDSVLAMIAR VQSYVPGYRL KQEVQFERFG
260 270 280 290 300
SNRPLKIPGY GEFEGLKTSV FLEVEGAGDY LPNYSGNLDI MTAAAKAAGE
310
SLAKTHMEKT AA
Length:312
Mass (Da):32,847
Last modified:May 29, 2007 - v1
Checksum:i5E4C8274051EA8CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000676 Genomic DNA. Translation: ABP64098.1.
RefSeqiWP_010891016.1. NC_009426.1.

Genome annotation databases

EnsemblBacteriaiABP64098; ABP64098; Saro_3853.
KEGGinar:Saro_3853.
PATRICi22789601. VBINovAro50627_3451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000676 Genomic DNA. Translation: ABP64098.1.
RefSeqiWP_010891016.1. NC_009426.1.

3D structure databases

ProteinModelPortaliA4XDT7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP64098; ABP64098; Saro_3853.
KEGGinar:Saro_3853.
PATRICi22789601. VBINovAro50627_3451.

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiTHIEMGA.
OrthoDBiEOG6H1PXH.

Enzyme and pathway databases

BioCyciNARO279238:GHBU-3864-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of plasmid pNL1 of Novosphingobium aromaticivorans DSM 12444."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Han C., Thomson S., Schmutz J., Larimer F., Land M., Kyrpides N.
    , Ivanova N., Fredrickson J., Romine M.F., Richardson P.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12444 / F199.

Entry informationi

Entry nameiACDH2_NOVAD
AccessioniPrimary (citable) accession number: A4XDT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.