Reviewed, UniProtKB/Swiss-Prot A4XD40 (KMO_SALTO)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	Strop_4419

Organism

Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP]

Taxonomic identifier

369723 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Kynurenine 3-monooxygenase		PRO_0000361944

Sequences

	Sequence		Length	Mass (Da)
	A4XD40-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 53AF035F34109243	FASTA	453	49,803
	10 20 30 40 50 60 MNRRRERVVV VGAGLAGSLV ALYLARQGHE VDVFERRPDP RSALGRPEGR SINLGLSARG 70 80 90 100 110 120 MRALDGVGLL ADVLKHSVPM RDRVVHSPDG GIRTQPYGVR EHEILHSVLR EELISLVVTA 130 140 150 160 170 180 AEAEPGVRFH FDSLLASLDR ETGTVDVAPT AGGETRTVTA DLIVGADGAF STIRQQMQHG 190 200 210 220 230 240 LRANYAQEFL PWGYKELTIP VDADGQPRVR LEALHVWPGH EAMMIAHPNR DGSLTCTLFM 250 260 270 280 290 300 AHEGPVSFAA LDTPTAVRDF FRQRFPDAEE LMPDLVREVT EHPVGHLVTV RSDPWRYADR 310 320 330 340 350 360 VVLIGDAAHA VYPFYGQGMN SAFEDCVVLD ECLTAHPDRA TALAAYEAAR KPHTDVLADL 370 380 390 400 410 420 STANFEDLRD RVHRLGYSAS AAADRLLARL LPQHWVPLYG MVAHTTIPYA DALARAKRQD 430 440 450 RILRQAGAGL ALVTVLAATA ALRAGRRRRA NRR

References

[1]

"Complete sequence of Salinispora tropica CNB-440." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000667 Genomic DNA. Translation: ABP56847.1.
RefSeq	YP_001161225.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4XD40.
Genome annotation databases
GeneID	5060905.
GenomeReviews	Gene locus Strop_4419 in contig CP000667_GR.
KEGG	stp:Strop_4419.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0654.
HOGENOM	HBG430104.
OMA	EHKVKSV.
PhylomeDB	A4XD40.
Family and domain databases
InterPro	IPR002938. mOase_FAD_bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_SALTO

Accession

Primary (citable) accession number: A4XD40

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 29, 2007
Last modified:	January 19, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)