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A4XD40 (KMO_SALTO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9
Alternative name(s):
Kynurenine 3-hydroxylase
Gene names
Name:kmo
Ordered Locus Names:Strop_4419
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP]
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.

Catalytic activity

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.

Cofactor

FAD By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.

Sequence similarities

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandFAD
Flavoprotein
NADP
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionkynurenine 3-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Kynurenine 3-monooxygenase
PRO_0000361944

Sequences

Sequence LengthMass (Da)Tools
A4XD40 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 53AF035F34109243

FASTA45349,803
        10         20         30         40         50         60 
MNRRRERVVV VGAGLAGSLV ALYLARQGHE VDVFERRPDP RSALGRPEGR SINLGLSARG 

        70         80         90        100        110        120 
MRALDGVGLL ADVLKHSVPM RDRVVHSPDG GIRTQPYGVR EHEILHSVLR EELISLVVTA 

       130        140        150        160        170        180 
AEAEPGVRFH FDSLLASLDR ETGTVDVAPT AGGETRTVTA DLIVGADGAF STIRQQMQHG 

       190        200        210        220        230        240 
LRANYAQEFL PWGYKELTIP VDADGQPRVR LEALHVWPGH EAMMIAHPNR DGSLTCTLFM 

       250        260        270        280        290        300 
AHEGPVSFAA LDTPTAVRDF FRQRFPDAEE LMPDLVREVT EHPVGHLVTV RSDPWRYADR 

       310        320        330        340        350        360 
VVLIGDAAHA VYPFYGQGMN SAFEDCVVLD ECLTAHPDRA TALAAYEAAR KPHTDVLADL 

       370        380        390        400        410        420 
STANFEDLRD RVHRLGYSAS AAADRLLARL LPQHWVPLYG MVAHTTIPYA DALARAKRQD 

       430        440        450 
RILRQAGAGL ALVTVLAATA ALRAGRRRRA NRR

« Hide

References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000667 Genomic DNA. Translation: ABP56847.1.
RefSeqYP_001161225.1. NC_009380.1.

3D structure databases

ProteinModelPortalA4XD40.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4XD40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5060905.
GenomeReviewsGene locus Strop_4419 in contig CP000667_GR.
KEGGstp:Strop_4419.
PATRIC23448100. VBISalTro43511_4570.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0654.
HOGENOMHBG430104.
OMAWGYKELT.
PhylomeDBA4XD40.
ProtClustDBCLSK903475.

Enzyme and pathway databases

BioCycSTRO369723:STROP_4419-MONOMER.

Family and domain databases

InterProIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
KOK00486.
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Entry information

Entry nameKMO_SALTO
AccessionPrimary (citable) accession number: A4XD40
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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