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A4XCN2 (A4XCN2_SALTO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108
Gene names
Name:ispD HAMAP MF_00108
Ordered Locus Names:Strop_4261
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP] EMBL ABP56689.1
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site381Transition state stabilizer By similarity HAMAP MF_00108
Site451Transition state stabilizer By similarity HAMAP MF_00108
Site1751Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2281Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A4XCN2 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 093E1118779D58AB

FASTA24625,082
        10         20         30         40         50         60 
MSYPICHEEI IEDRDVTAQL DPRGDVAVLV PAAGAGVRLG PGRPKALRLL GGEPLLVHAV 

        70         80         90        100        110        120 
RRLAAAASVH TVVVAAPAAD LVAVRELLAP VAPVTVVAGG VQRQASVAAA LAAVPAGPEI 

       130        140        150        160        170        180 
VLVHDAARAL TPPGLVESVA AAVRSGHDAV IPVLPVVDTI KEIGVGERVL GTVDRSALRA 

       190        200        210        220        230        240 
VQTPQGFRRG VLTTAHAAAT DPLTDDAGLV EKLGVPVVCV PGSEHALKIT RPFDLALAEH 


LLAMGR

« Hide

References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000667 Genomic DNA. Translation: ABP56689.1.
RefSeqYP_001161067.1. NC_009380.1.

3D structure databases

ProteinModelPortalA4XCN2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4XCN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5060746.
GenomeReviewsGene locus Strop_4261 in contig CP000667_GR.
KEGGstp:Strop_4261.
PATRIC23447770. VBISalTro43511_4406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1211.
HOGENOMHBG672839.
OMASKVIVVC.
PhylomeDBA4XCN2.
ProtClustDBCLSK970009.

Enzyme and pathway databases

BioCycSTRO369723:STROP_4261-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4XCN2_SALTO
AccessionPrimary (citable) accession number: A4XCN2
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info