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A4XC73

- GSA_SALTO

UniProt

A4XC73 - GSA_SALTO

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSTRO369723:GI49-4153-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Strop_4100
    OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
    Taxonomic identifieri369723 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
    ProteomesiUP000000235: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382367Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi369723.Strop_4100.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XC73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRFMVSGN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XC73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVFPAGPG RYPAAAPASE ALFDRACAIV PGGVNSPVRA FRAVGGTPRF    50
    IVRGEGPWLY DADGRRYVDL VCSWGPMILG HAHPAVVEAL RSAAALGTSF 100
    GAPTPGEVEL AAEIVDRAPV EQVRLVNSGT EATMSAIRLA RGYTGRTRII 150
    KFAGCYHGHS DALLAAAGSG VATLGLPDSP GVTGAAAGDT IVLPYNDLAA 200
    VEAVFAAEGP QIAAVITESA AGNMGVVAPR DNFNQRLAAV AHANGALLIV 250
    DEVMTGFRVS RAGWHGLDPC AADLWTYGKV MGGGLPAAAF GGRAEIMSQL 300
    APVGPVYQAG TLSGNPLACA AGLATLRLAD DALYRRLDET AAVVGRLAGE 350
    ALAAAGVPHR LSSAGNMFSV FFTDADVFDY ATASAQQVPA FKAFFHAMLA 400
    AGVYLPPSAF ESWFVSAAID DAALEQIAAA LPAAAAAAAE VHGGSDGE 448
    Length:448
    Mass (Da):45,598
    Last modified:May 29, 2007 - v1
    Checksum:iDE54F5C032F87E07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000667 Genomic DNA. Translation: ABP56530.1.
    RefSeqiYP_001160908.1. NC_009380.1.

    Genome annotation databases

    EnsemblBacteriaiABP56530; ABP56530; Strop_4100.
    GeneIDi5060582.
    KEGGistp:Strop_4100.
    PATRICi23447430. VBISalTro43511_4239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000667 Genomic DNA. Translation: ABP56530.1 .
    RefSeqi YP_001160908.1. NC_009380.1.

    3D structure databases

    ProteinModelPortali A4XC73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 369723.Strop_4100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP56530 ; ABP56530 ; Strop_4100 .
    GeneIDi 5060582.
    KEGGi stp:Strop_4100.
    PATRICi 23447430. VBISalTro43511_4239.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RFMVSGN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci STRO369723:GI49-4153-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Salinispora tropica CNB-440."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

    Entry informationi

    Entry nameiGSA_SALTO
    AccessioniPrimary (citable) accession number: A4XC73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3