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A4XBI0 (ALR_SALTO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:Strop_3857
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP]
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Alanine racemase HAMAP-Rule MF_01201
PRO_1000085507

Sites

Active site331Proton acceptor; specific for D-alanine By similarity
Active site2611Proton acceptor; specific for L-alanine By similarity
Binding site1311Substrate By similarity
Binding site3091Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue331N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4XBI0 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: C4E9E1D89EABDB68

FASTA37239,213
        10         20         30         40         50         60 
MWQAEVRVDL DAIRENVSWL RSGSAAELMA VVKGDGYGHG MVPAAHAALD GGADWLGVCT 

        70         80         90        100        110        120 
LDEALTLRRA GITVPVLAWL LAPGLPLHEG VTAGIDLGVA SVAQLEEMVE AGRVAGRPAR 

       130        140        150        160        170        180 
LHLKIDTGLS RGGATISEWP ELLDAAAKAQ ADGAVEVVGV WSHFVYADAP GHPTTDRQLA 

       190        200        210        220        230        240 
VFHEGLGMVE KAGLRPRYRH LANSAATLTR PDAHFDLVRP GLAVYGLSPV AGERFGLRPA 

       250        260        270        280        290        300 
MTARARVMLT KQVPAGAGVS YGHTYTTDRA SNLAVIPLGY ADGVPRDASN SGPVQLGGVR 

       310        320        330        340        350        360 
RTISGRVCMD QFVLDCGDDP VAPGDVATLF GTGRDGEPTA DDWAEAVGTI NYEIVTRFGS 

       370 
TRVPRCYDGE RP 

« Hide

References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000667 Genomic DNA. Translation: ABP56287.1.
RefSeqYP_001160665.1. NC_009380.1.

3D structure databases

ProteinModelPortalA4XBI0.
SMRA4XBI0. Positions 5-369.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING369723.Strop_3857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP56287; ABP56287; Strop_3857.
GeneID5060335.
KEGGstp:Strop_3857.
PATRIC23446906. VBISalTro43511_3981.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMAINNQLAP.
OrthoDBEOG6PP9NJ.
ProtClustDBCLSK969849.

Enzyme and pathway databases

BioCycSTRO369723:GI49-3906-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_SALTO
AccessionPrimary (citable) accession number: A4XBI0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways