A4XAL2
KYNU_SALTO
Kynureninase
3.7.1.3
L-kynurenine hydrolase
kynU
Strop_3530
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC 105044 / CNB-440)
Bacteria
Actinomycetota
Actinomycetes
Micromonosporales
Micromonosporaceae
Salinispora
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica.
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
H2O + L-kynurenine = anthranilate + H(+) + L-alanine
3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine
pyridoxal 5'-phosphate
Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
Homodimer.
Belongs to the kynureninase family.
Hydrolase
Pyridine nucleotide biosynthesis
Pyridoxal phosphate
Reference proteome
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
pyridoxal 5'-phosphate
MREEELIQEEKAANRLDTADPGHRHLFHVPPADGGRYQQAAYLAGNSLGLQPRATRDELFADLEAWRRLGVEGHLAADRPWLPYHELLTAPTARLVGARPAEVVVMNSLTVNLHLLMVSFYRPTGVRTRIVIEDSAFPSDSYAVRSQARFHGLDPDSTVVRLAPRPGEDTLRTADVRDLLAAEGDTIALVLLGGVNYLTGELMEIPEITAAGRAAGAVVGWDLAHAAGNVPLALHDWDVDFAAWCSYKYLNSGPGGLSGVFVHERHLADPTLPRFEGWWSTEAATRFEMSPVARPPATAEAWQVSNPPILAMGPVRTSLEVFDSVGMTALRERSVRLTGYLEWLLDQVTPGRPLAVVTPRDPDRRGAQLSVRIGTGSAAELAKRLRLEHGVVADAREPDVVRFAPVPLYSTYHDCWRVADALAATVEVH
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