A4XAK8 (ACDH_SALTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Ordered Locus Names:

Strop_3526

Organism

Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP]

Taxonomic identifier

369723 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000387738
Regions
	Nucleotide binding	10 – 13	4	NAD By similarity
	Nucleotide binding	159 – 167	9	NAD By similarity
Sites
	Binding site	285	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4XAK8 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: BAEF104DA56F0635	FASTA	308	32,155
	10 20 30 40 50 60 MSVGVAVLGS GNIGTDLMIK VLRLSDSLRM VAMAGIDPDS DGLARARRLG VTTTAEGVAG 70 80 90 100 110 120 LVALPEFADV ALVFDATSAG AHRHHDAVLR AHGRTVVDLT PAAVGPYVVP PVNLDEHLRE 130 140 150 160 170 180 TNVNMVTCGG QATVPIVAAV GRVTPVTYGE IVASIAAKSA GPGTRANIDE FTETTARAIE 190 200 210 220 230 240 VVGGAELGKA IIVLNPADPP LLMRDTVYCL CPDTDADRSA IAAAIADMVR AVQEYVPGYC 250 260 270 280 290 300 LKQDVQFDRV DSYLPALGRR LTGLQVSTFL EVSGAGHYLP TYAGNLDIMT SAALRTAERL IARRAVTA

References

[1]

"Complete sequence of Salinispora tropica CNB-440." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000667 Genomic DNA. Translation: ABP55957.1.
RefSeq	YP_001160335.1. NC_009380.1.
3D structure databases
ProteinModelPortal	A4XAK8.
ModBase	Search...
Protein-protein interaction databases
STRING	A4XAK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5060000.
GenomeReviews	Gene locus Strop_3526 in contig CP000667_GR.
KEGG	stp:Strop_3526.
PATRIC	23446216. VBISalTro43511_3640.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HBG300125.
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	STRO369723:STROP_3526-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_SALTO

Accession

Primary (citable) accession number: A4XAK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	May 29, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program