Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4X9S8

- SYL_SALTO

UniProt

A4X9S8 - SYL_SALTO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei732 – 7321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTRO369723:GI49-3261-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Strop_3225
    OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
    Taxonomic identifieri369723 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
    ProteomesiUP000000235: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Leucine--tRNA ligasePRO_1000091362Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi369723.Strop_3225.

    Structurei

    3D structure databases

    ProteinModelPortaliA4X9S8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi67 – 7812"HIGH" regionAdd
    BLAST
    Motifi729 – 7335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4X9S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEAAAPASD IPPFRYTADL ADEIERRWQD TWEREGTFHA PNPTGPLADP    50
    EHPRAGAEKL YVLDMFPYPS GAGLHVGHPL GYIGTDCFAR YQRMAGRNVL 100
    HAMGFDAFGL PAEQYAVQTG THPRTTTEAN IARYKAQLRR LGLAHDERRS 150
    VATIDADFYR WTQWVFLQIY NAWYDSSAKR ARPIAELVAE FSGGSRRTPD 200
    GRPWGELTDA ERRAVVDQHR LAYVSQAPVN WCPGLGTVLA NEEVTADGRS 250
    ERGNFPVFKR NLKQWMMRIT AYGDRLLDDL EKLDWPEPIK LMQRNWIGRS 300
    TGAHIEFPTS APDSDAEGEP RISVFTTRPD TIFGATYLVL APEHDLVDTL 350
    VPTAWPAGVP QAWTGGQASP REAVAGYRKV AAAKTDLERQ AETKEKTGVF 400
    IGSYATNPVT GAQIPIFIAD YVLAGYGTGA IMAVPGQDER DWAFAEVFDL 450
    PIVRTVQPAE GFAGKAYTGD GLAINSATPE RGLDLNGLGV AEAKARTIAW 500
    LEAGGHGSGA VTYRLRDWLF SRQRYWGEPF PIVYDETGAA IALPEELLPV 550
    ELPEVDDFAP RTFDPSDAES NPETPLSRRR DWVEVELDLG DGPKRYTRET 600
    NVMPQWAGSC WYELRYLDPT NGDRFVDPEA ERYWMGPRGE GDCGGTDLYV 650
    GGAEHAVLHL LYARFWHKVL YDLGHVSSFE PFRKLFNQGY IQAYAYTDAR 700
    GAYVPAEEVV ERSGTYYLGD VQVNREYGKM GKSLRNVVTP DEMCAAYGAD 750
    TFRVYEMSMG PLEVSRPWET RAVVGSFRFL QRVWRAIVDE RSGASRVVDV 800
    PADEATRRLL HRIVDGVRGD MEAMRFNTTI AKLIELTNAL TRLPETPREV 850
    AEPLVLMLAP FAPHVAEELW RRMGHETSLT YADFPVADPA LLVAESVTYP 900
    VQVNGKVRGR IEVPADAGQE TVRAAALEAV AASLAGKEPR KVIVVPGRMV 950
    SVVA 954
    Length:954
    Mass (Da):106,010
    Last modified:May 29, 2007 - v1
    Checksum:i46A367CA446A4CB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000667 Genomic DNA. Translation: ABP55659.1.
    RefSeqiYP_001160037.1. NC_009380.1.

    Genome annotation databases

    EnsemblBacteriaiABP55659; ABP55659; Strop_3225.
    GeneIDi5059690.
    KEGGistp:Strop_3225.
    PATRICi23445554. VBISalTro43511_3317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000667 Genomic DNA. Translation: ABP55659.1 .
    RefSeqi YP_001160037.1. NC_009380.1.

    3D structure databases

    ProteinModelPortali A4X9S8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 369723.Strop_3225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP55659 ; ABP55659 ; Strop_3225 .
    GeneIDi 5059690.
    KEGGi stp:Strop_3225.
    PATRICi 23445554. VBISalTro43511_3317.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci STRO369723:GI49-3261-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Salinispora tropica CNB-440."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

    Entry informationi

    Entry nameiSYL_SALTO
    AccessioniPrimary (citable) accession number: A4X9S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3