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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei732 – 7321ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTRO369723:GI49-3261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Strop_3225
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
ProteomesiUP000000235 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Leucine--tRNA ligasePRO_1000091362Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi369723.Strop_3225.

Structurei

3D structure databases

ProteinModelPortaliA4X9S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 7812"HIGH" regionAdd
BLAST
Motifi729 – 7335"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4X9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAAAPASD IPPFRYTADL ADEIERRWQD TWEREGTFHA PNPTGPLADP
60 70 80 90 100
EHPRAGAEKL YVLDMFPYPS GAGLHVGHPL GYIGTDCFAR YQRMAGRNVL
110 120 130 140 150
HAMGFDAFGL PAEQYAVQTG THPRTTTEAN IARYKAQLRR LGLAHDERRS
160 170 180 190 200
VATIDADFYR WTQWVFLQIY NAWYDSSAKR ARPIAELVAE FSGGSRRTPD
210 220 230 240 250
GRPWGELTDA ERRAVVDQHR LAYVSQAPVN WCPGLGTVLA NEEVTADGRS
260 270 280 290 300
ERGNFPVFKR NLKQWMMRIT AYGDRLLDDL EKLDWPEPIK LMQRNWIGRS
310 320 330 340 350
TGAHIEFPTS APDSDAEGEP RISVFTTRPD TIFGATYLVL APEHDLVDTL
360 370 380 390 400
VPTAWPAGVP QAWTGGQASP REAVAGYRKV AAAKTDLERQ AETKEKTGVF
410 420 430 440 450
IGSYATNPVT GAQIPIFIAD YVLAGYGTGA IMAVPGQDER DWAFAEVFDL
460 470 480 490 500
PIVRTVQPAE GFAGKAYTGD GLAINSATPE RGLDLNGLGV AEAKARTIAW
510 520 530 540 550
LEAGGHGSGA VTYRLRDWLF SRQRYWGEPF PIVYDETGAA IALPEELLPV
560 570 580 590 600
ELPEVDDFAP RTFDPSDAES NPETPLSRRR DWVEVELDLG DGPKRYTRET
610 620 630 640 650
NVMPQWAGSC WYELRYLDPT NGDRFVDPEA ERYWMGPRGE GDCGGTDLYV
660 670 680 690 700
GGAEHAVLHL LYARFWHKVL YDLGHVSSFE PFRKLFNQGY IQAYAYTDAR
710 720 730 740 750
GAYVPAEEVV ERSGTYYLGD VQVNREYGKM GKSLRNVVTP DEMCAAYGAD
760 770 780 790 800
TFRVYEMSMG PLEVSRPWET RAVVGSFRFL QRVWRAIVDE RSGASRVVDV
810 820 830 840 850
PADEATRRLL HRIVDGVRGD MEAMRFNTTI AKLIELTNAL TRLPETPREV
860 870 880 890 900
AEPLVLMLAP FAPHVAEELW RRMGHETSLT YADFPVADPA LLVAESVTYP
910 920 930 940 950
VQVNGKVRGR IEVPADAGQE TVRAAALEAV AASLAGKEPR KVIVVPGRMV

SVVA
Length:954
Mass (Da):106,010
Last modified:May 29, 2007 - v1
Checksum:i46A367CA446A4CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP55659.1.
RefSeqiWP_012014436.1. NC_009380.1.

Genome annotation databases

EnsemblBacteriaiABP55659; ABP55659; Strop_3225.
GeneIDi5059690.
KEGGistp:Strop_3225.
PATRICi23445554. VBISalTro43511_3317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP55659.1.
RefSeqiWP_012014436.1. NC_009380.1.

3D structure databases

ProteinModelPortaliA4X9S8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi369723.Strop_3225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP55659; ABP55659; Strop_3225.
GeneIDi5059690.
KEGGistp:Strop_3225.
PATRICi23445554. VBISalTro43511_3317.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciSTRO369723:GI49-3261-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Salinispora tropica CNB-440."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

Entry informationi

Entry nameiSYL_SALTO
AccessioniPrimary (citable) accession number: A4X9S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.