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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Strop_3215
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei125 – 145HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei294 – 314HelicalUniRule annotationAdd BLAST21
Transmembranei350 – 370HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000745591 – 374Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST374

Proteomic databases

PRIDEiA4X9R8

Interactioni

Protein-protein interaction databases

STRINGi369723.Strop_3215

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4X9R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVIVAVGV AFLVSLFCTP IAIKVFTRLK AGQPIRAEGP VMHQGKKGTP
60 70 80 90 100
TMGGVVFILA TVIAYVAGHL ALTTLPDAQI AQVEPTITAL VLLGLMVFSG
110 120 130 140 150
AVGFIDDFLK VRKRHSGGLN KRGKLLGQIL VGAVFGVIAL YFPSTMTDSQ
160 170 180 190 200
GTLTNTETVG STTLSFIRDI PALELTKVGA VVLFIFVVMA ATNGVNLTDG
210 220 230 240 250
LDGLATGASV MVLAAYALIA FWQYRHWCAD PNYTQEYCYA VRDPLEVALI
260 270 280 290 300
AGAAAGACVG FLWWNTSPAR IFMGDTGALG LGGLIAGMAM STRTILLLPI
310 320 330 340 350
IGGLFVIITM SVVIQIISFR TTGKRVFRMS PLQHHFELAG WSEVNIVVRF
360 370
WIIAGIGVAI ALGLFYSEFL ARVG
Length:374
Mass (Da):39,784
Last modified:May 29, 2007 - v1
Checksum:iDD9B831B02585F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP55649.1
RefSeqiWP_012014426.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP55649; ABP55649; Strop_3215
GeneIDi5059680
KEGGistp:Strop_3215
PATRICifig|369723.5.peg.3307

Similar proteinsi

Entry informationi

Entry nameiMRAY_SALTO
AccessioniPrimary (citable) accession number: A4X9R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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