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Protein

UvrABC system protein C

Gene

uvrC

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Strop_3109
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000778321 – 665UvrABC system protein CAdd BLAST665

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi369723.Strop_3109

Structurei

3D structure databases

ProteinModelPortaliA4X9H1
SMRiA4X9H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 95GIY-YIGUniRule annotationAdd BLAST80
Domaini208 – 243UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279962
KOiK03703
OMAiLFPIRQC
OrthoDBiPOG091H01BS

Family and domain databases

Gene3Di3.30.420.340, 2 hits
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

A4X9H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPSSYRPA PGTIPESPGV YRFRDGTGRV IYVGKARNLR NRLNSYFADP
60 70 80 90 100
VNLHQRTRQM VFTAESVDWI SVATEVEALQ QEFTEIKQYD PRFNVRYRDD
110 120 130 140 150
KSYPYLAVTV SEEFPRLQVM RGAKRKGVRY FGPYSHAWAI RETLDLLLRV
160 170 180 190 200
FPARTCSSGV FKRAGQVGRP CLLGYIDKCA APCVGSVSAE EHRAIVEGFC
210 220 230 240 250
DFMAGRTDLM VRRLEREMAD ASAELEFERA ARLRDDLAAL RRAMEKQTVV
260 270 280 290 300
FGDGTDADVV AFADDPLEAA VQVFHVRDGR IRGQRGWVVE KTEELTIGDL
310 320 330 340 350
VHHFCTQVYG GEQGEADVPR ELLVPELPAD VEALADWLSD HRGSRVTLRV
360 370 380 390 400
PQRGDKRALL ETVARNATDA LARHKLKRAG DLTTRSKALD EIAETLGLQT
410 420 430 440 450
APLRIECYDI SQIQGTDVVA SMVVFEDGLP RKSEYRRFII RGATDDLSAM
460 470 480 490 500
SEVLRRRFAR YLDARAETGE AGVESAGDPA TPAGPASTGP GVPDEPRVGT
510 520 530 540 550
LVDPTTGRPR KFAYPPQLVV VDGGAPQVAA AAQALAELGV DDVALCGLAK
560 570 580 590 600
RLEEVWLPDD DFPAILPRTS EGLYLLQRVR DEAHRFAITF HRQRRSRRMT
610 620 630 640 650
ESALDRVPGL GEVRRKALLR HFGSLKRLSA ASVEEITEVP GVGQRTAEAI
660
LAALGDSTQP DEPRT
Length:665
Mass (Da):73,708
Last modified:May 29, 2007 - v1
Checksum:i0002825DC6F4A3C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP55545.1
RefSeqiWP_012014322.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP55545; ABP55545; Strop_3109
GeneIDi5059573
KEGGistp:Strop_3109
PATRICifig|369723.5.peg.3200

Similar proteinsi

Entry informationi

Entry nameiUVRC_SALTO
AccessioniPrimary (citable) accession number: A4X9H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health