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Protein

UvrABC system protein C

Gene

uvrC

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciSTRO369723:GI49-3144-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Strop_3109
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000000235: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665UvrABC system protein CPRO_1000077832Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi369723.Strop_3109.

Structurei

3D structure databases

ProteinModelPortaliA4X9H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580GIY-YIGUniRule annotationAdd
BLAST
Domaini208 – 24336UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4X9H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPSSYRPA PGTIPESPGV YRFRDGTGRV IYVGKARNLR NRLNSYFADP
60 70 80 90 100
VNLHQRTRQM VFTAESVDWI SVATEVEALQ QEFTEIKQYD PRFNVRYRDD
110 120 130 140 150
KSYPYLAVTV SEEFPRLQVM RGAKRKGVRY FGPYSHAWAI RETLDLLLRV
160 170 180 190 200
FPARTCSSGV FKRAGQVGRP CLLGYIDKCA APCVGSVSAE EHRAIVEGFC
210 220 230 240 250
DFMAGRTDLM VRRLEREMAD ASAELEFERA ARLRDDLAAL RRAMEKQTVV
260 270 280 290 300
FGDGTDADVV AFADDPLEAA VQVFHVRDGR IRGQRGWVVE KTEELTIGDL
310 320 330 340 350
VHHFCTQVYG GEQGEADVPR ELLVPELPAD VEALADWLSD HRGSRVTLRV
360 370 380 390 400
PQRGDKRALL ETVARNATDA LARHKLKRAG DLTTRSKALD EIAETLGLQT
410 420 430 440 450
APLRIECYDI SQIQGTDVVA SMVVFEDGLP RKSEYRRFII RGATDDLSAM
460 470 480 490 500
SEVLRRRFAR YLDARAETGE AGVESAGDPA TPAGPASTGP GVPDEPRVGT
510 520 530 540 550
LVDPTTGRPR KFAYPPQLVV VDGGAPQVAA AAQALAELGV DDVALCGLAK
560 570 580 590 600
RLEEVWLPDD DFPAILPRTS EGLYLLQRVR DEAHRFAITF HRQRRSRRMT
610 620 630 640 650
ESALDRVPGL GEVRRKALLR HFGSLKRLSA ASVEEITEVP GVGQRTAEAI
660
LAALGDSTQP DEPRT
Length:665
Mass (Da):73,708
Last modified:May 29, 2007 - v1
Checksum:i0002825DC6F4A3C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP55545.1.
RefSeqiYP_001159923.1. NC_009380.1.

Genome annotation databases

EnsemblBacteriaiABP55545; ABP55545; Strop_3109.
GeneIDi5059573.
KEGGistp:Strop_3109.
PATRICi23445318. VBISalTro43511_3200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP55545.1.
RefSeqiYP_001159923.1. NC_009380.1.

3D structure databases

ProteinModelPortaliA4X9H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi369723.Strop_3109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP55545; ABP55545; Strop_3109.
GeneIDi5059573.
KEGGistp:Strop_3109.
PATRICi23445318. VBISalTro43511_3200.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Enzyme and pathway databases

BioCyciSTRO369723:GI49-3144-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Salinispora tropica CNB-440."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

Entry informationi

Entry nameiUVRC_SALTO
AccessioniPrimary (citable) accession number: A4X9H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: February 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.