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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Strop_2522
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000835971 – 380Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST380

Interactioni

Protein-protein interaction databases

STRINGi369723.Strop_2522

Structurei

3D structure databases

ProteinModelPortaliA4X7W7
SMRiA4X7W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A4X7W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYDLPPLRE PDLPRTAKVR PVALRTGWTT GACATAATKA ALTALVTGVS
60 70 80 90 100
PEQVEIGLPA GRRVCFPVAR CDRTADGVEA VVVKDAGDDP DVTHGAELTA
110 120 130 140 150
TVGWRWVPGL ALEGGPGVGT VTKPGLGLTV GGPAINDTPR RMIGEAVAEV
160 170 180 190 200
VDLAVVGVRV VISVPRGEIM ARKTTNRRLG IIGGISILGT TGVVRPFSTA
210 220 230 240 250
SWRASVVQAV QVAAAQGEQT VVLCTGGRTE RAARELLPEL PEVCFVEVGD
260 270 280 290 300
FTGAAVTAAV THGLSGVAFV GMAGKLAKLA AGVLMTHYTR SKVDLSLLGA
310 320 330 340 350
VTVEAGGSAD LAAAVTAANT GRHAYELWEA AGLLGPAGDL LCRRVRTVLR
360 370 380
RFAGDAVTVD VAMVDFAGAR RVAASGRWSQ
Length:380
Mass (Da):39,051
Last modified:May 29, 2007 - v1
Checksum:i807A30049CD65B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP54967.1
RefSeqiWP_012013748.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP54967; ABP54967; Strop_2522
GeneIDi5058985
KEGGistp:Strop_2522
PATRICifig|369723.5.peg.2599

Similar proteinsi

Entry informationi

Entry nameiCBID_SALTO
AccessioniPrimary (citable) accession number: A4X7W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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