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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha

Gene

accD

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity).By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15ZincBy similarity1
Metal bindingi18ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi37ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (EC:6.4.1.2)
Short name:
ACCase subunits beta/alpha
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha
Gene namesi
Name:accD
Synonyms:accA, accDA
Ordered Locus Names:Strop_2505
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591171 – 566Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alphaAdd BLAST566

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.By similarity

Protein-protein interaction databases

STRINGi369723.Strop_2505.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 280CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST270
Domaini282 – 534CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 243Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaBy similarityAdd BLAST243
Regioni11 – 534CarboxyltransferasePROSITE-ProRule annotationAdd BLAST524
Regioni244 – 557Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaBy similarityAdd BLAST314

Sequence similaritiesi

In the N-terminal section; belongs to the AccD/PCCB family.Curated
In the C-terminal section; belongs to the AccA family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG0777. LUCA.
COG0825. LUCA.
HOGENOMiHOG000244564.
KOiK01962.
K01963.
OMAiRVLMCAN.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
MF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR001095. Acetyl_CoA_COase_a_su.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A4X7V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPTTPRGGQ LWSRCGGCAS LLYRKRLRRN LDVCPECGAH SRLDAPARLA
60 70 80 90 100
QLVDPGSFTA LADRAPEVDP IGFVDVLPYP HRLTAARSGT GLAEAVVCGT
110 120 130 140 150
ATVAGSRCVI AVMDFRFLGG SLGCAVGELI TQAAERALAD RVPLVVVTAS
160 170 180 190 200
GGARMQEGVL SLMQMATVSQ AVAALRESGV PSVSVLTDPT YGGVAASFAT
210 220 230 240 250
NTDVVIAESG ARMGFAGPRV IRQVTGRELP DGFQTAEFLL RHGQVDLVVP
260 270 280 290 300
RHALRGCLAT LLAAASGGRE PVGAGHESEC PPVDGSSTQE RGADKRDAWE
310 320 330 340 350
TVRLARHPGR PTTLDYLETA FDSFVELHGD RLGADCPAVV GGLAELAGRP
360 370 380 390 400
VLVVGHQKGH TTGDLMSRNF GMASPAGHRK ALRLARLAAR WGLPVVTLVD
410 420 430 440 450
TPGADPGVGA EEQGQAAAIA ENILTLTMLP TPVVAVITGE GGSGGALALA
460 470 480 490 500
VADRVLMLEH AVYSVISPEG CAAILWPDRS AAPQAARALR LTSADLCRLG
510 520 530 540 550
VVDAVVPEPA PAAHHDPPAA MQAVREAVLA HLVPLLEVPT ATLVRRRRRR
560
FRRFGAAGLG ARAGAR
Length:566
Mass (Da):58,867
Last modified:May 29, 2007 - v1
Checksum:i36CCFAB7707D5AEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP54951.1.
RefSeqiWP_012013732.1. NC_009380.1.

Genome annotation databases

EnsemblBacteriaiABP54951; ABP54951; Strop_2505.
GeneIDi5058968.
KEGGistp:Strop_2505.
PATRICifig|369723.5.peg.2581.

Similar proteinsi

Entry informationi

Entry nameiACCDA_SALTO
AccessioniPrimary (citable) accession number: A4X7V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 29, 2007
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families