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Protein

Catalase-peroxidase

Gene

katG

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei125Transition state stabilizerUniRule annotation1
Active sitei129Proton acceptorUniRule annotation1
Metal bindingi291Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Strop_2054
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549031 – 758Catalase-peroxidaseAdd BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki128 ↔ 250Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-276)UniRule annotation
Cross-linki250 ↔ 276Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-128)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi369723.Strop_2054.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4X6K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTQDNAPV SAQGVDQKAA AGCPVAHDSV TAHGSESESP AIDSPSAVGG
60 70 80 90 100
GRPRTNRDWW PNQLDLSVLS TNSAKVNPLG EDFSYAKEFA KLDVEALKRD
110 120 130 140 150
ITEVLTTSQD WWPADFGHYG GLMIRLSWHA AGTYRIHDGR GGAGDGGQRF
160 170 180 190 200
APLNSWPDNV NLDKARRLLW PVKQKYGQKI SWADLLVLAG NVALESMGFK
210 220 230 240 250
TFGFGFGRED VWEPEEIFWG PEDTWLGDER YVSEKEFSAG VGATEMGLIY
260 270 280 290 300
VNPEGPRGNA DPASAAHFIR ETFRRMAMND EETVALIAGG HTFGKTHGAG
310 320 330 340 350
VADDHVGPEP EGAPLEAQGL GWMSSHASGV GADTISSGLE VTWTDRPTQW
360 370 380 390 400
SNRFFEILFG YEWELTTSPG GAKQWVAKDA EAIIPDAYDS TKKHKPTMLT
410 420 430 440 450
TDLSLRVDPA YERISRRFLE NPDEFALAFA KAWYKLLHRD MGPVSRFLGP
460 470 480 490 500
WVPQTQLWQD PVPAVDHELV GAADIAALKA KVLESGLTTT QLVSTAWASA
510 520 530 540 550
ASFRHTDKRG GANGARIRLE PQRSWEVNQP EQLATVLPAL EEIQREFNAA
560 570 580 590 600
GGAKISLADL IVLAGSAAVE KAARDAGVEV TVPFRPGRTD ATQEQTDVDS
610 620 630 640 650
FRVLEPRADA FRNYLRPGEK TQPEVLLVDR AYLLNLTAPE MTVLIGGLRA
660 670 680 690 700
LEANAGGSRH GVLTDRPGVL TNDFFTNLLA SGARWKASES TEHAYEIRDV
710 720 730 740 750
ATDKVKWTAS AVDLIFGSNS QLRALAEVYA SEDAREKFVQ DFVAAWTKVM

ELDRFDLA
Length:758
Mass (Da):82,880
Last modified:May 29, 2007 - v1
Checksum:i8806AAC7990C19F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP54507.1.
RefSeqiWP_011905937.1. NC_009380.1.

Genome annotation databases

EnsemblBacteriaiABP54507; ABP54507; Strop_2054.
GeneIDi5058517.
KEGGistp:Strop_2054.
PATRICi23443130. VBISalTro43511_2107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP54507.1.
RefSeqiWP_011905937.1. NC_009380.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi369723.Strop_2054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP54507; ABP54507; Strop_2054.
GeneIDi5058517.
KEGGistp:Strop_2054.
PATRICi23443130. VBISalTro43511_2107.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SALTO
AccessioniPrimary (citable) accession number: A4X6K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.