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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Strop_1869
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000773181 – 308Methionyl-tRNA formyltransferaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi369723.Strop_1869

Structurei

3D structure databases

ProteinModelPortaliA4X631
SMRiA4X631
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A4X631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVIFAGTPA VAVPTLAAVA ASRHDLVAVL TRPDAPAGRG RGLSRSPVGA
60 70 80 90 100
WADEHGIEVL TPARPREPEF LDRLRALAPD CVPVVAYGAL VPPAALEIPR
110 120 130 140 150
HGWVNLHFSL LPAWRGAAPV QHALLHGDEL TGASVFQLEE GLDTGPVYGT
160 170 180 190 200
VTDEVRPADT SGDLLERLAH SGAELLIAVL DAIEEGSARA EPQPNDGVSL
210 220 230 240 250
APKLTVADAR VRWGDPAFAV DRRVRACSPA PGPWTTFRDE RVKLGPVTLV
260 270 280 290 300
AGGPELRPGE LLVEKSRVLA GTASTPVQLG EIRAAGKKAM PASDWARGVR

VTAGEVLA
Length:308
Mass (Da):32,341
Last modified:May 29, 2007 - v1
Checksum:i90E5209A8707AC29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP54331.1
RefSeqiWP_011905761.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP54331; ABP54331; Strop_1869
GeneIDi5058328
KEGGistp:Strop_1869
PATRICifig|369723.5.peg.1917

Similar proteinsi

Entry informationi

Entry nameiFMT_SALTO
AccessioniPrimary (citable) accession number: A4X631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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