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Protein

Chorismate synthase

Gene

aroC

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.UniRule annotation

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.UniRule annotation

Cofactori

FMNH2UniRule annotationNote: Reduced FMN (FMNH(2)).UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (Strop_3256), Phospho-2-dehydro-3-deoxyheptonate aldolase (Strop_1036), Phospho-2-dehydro-3-deoxyheptonate aldolase (Strop_3571)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. no protein annotated in this organism
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40NADPUniRule annotation1
Binding sitei46NADPUniRule annotation1
Binding sitei300FMN; via amide nitrogenUniRule annotation1
Binding sitei341FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi135 – 137FMNUniRule annotation3
Nucleotide bindingi256 – 257FMNUniRule annotation2
Nucleotide bindingi315 – 319FMNUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00090

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthaseUniRule annotation (EC:4.2.3.5UniRule annotation)
Short name:
CSUniRule annotation
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyaseUniRule annotation
Gene namesi
Name:aroCUniRule annotation
Ordered Locus Names:Strop_1845
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000790081 – 392Chorismate synthaseAdd BLAST392

Proteomic databases

PRIDEiA4X607

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi369723.Strop_1845

Structurei

3D structure databases

ProteinModelPortaliA4X607
SMRiA4X607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D10 Bacteria
COG0082 LUCA
HOGENOMiHOG000060334
KOiK01736
OMAiMLSINAV
OrthoDBiPOG091H00EG

Family and domain databases

CDDicd07304 Chorismate_synthase, 1 hit
Gene3Di3.60.150.10, 1 hit
HAMAPiMF_00300 Chorismate_synth, 1 hit
InterProiView protein in InterPro
IPR000453 Chorismate_synth
IPR035904 Chorismate_synth_AroC_sf
IPR020541 Chorismate_synthase_CS
PANTHERiPTHR21085 PTHR21085, 1 hit
PfamiView protein in Pfam
PF01264 Chorismate_synt, 1 hit
PIRSFiPIRSF001456 Chorismate_synth, 1 hit
SUPFAMiSSF103263 SSF103263, 1 hit
TIGRFAMsiTIGR00033 aroC, 1 hit
PROSITEiView protein in PROSITE
PS00787 CHORISMATE_SYNTHASE_1, 1 hit
PS00788 CHORISMATE_SYNTHASE_2, 1 hit
PS00789 CHORISMATE_SYNTHASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A4X607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWLTAGES HGPALVALLE GVPAGVEVTT EEIAGELARR RLGYGRGARM
60 70 80 90 100
AFEQDEIEII GGLRHGVTLG SPVAIRVGNS EWPKWRTVMA PDPVDSTELA
110 120 130 140 150
GQARNAPLTR PRPGHADLAG MQKYGHTDAR PILERASARE TAARVAVGTV
160 170 180 190 200
AKALLRQALG IEVVSHVVEL GTVATKPGLR PSPADGDRID ADPLRCLDPE
210 220 230 240 250
ASVRMVAEVD AAKKDADTLG GVVEVLAYGV PPGLGSHVQW DRKLDARLAT
260 270 280 290 300
ALMSIQAIKG VEIGDGWQQA RSRGSVAHDE IIPTATGVRR VTDRAGGLEG
310 320 330 340 350
GITTGEPLRV RAAMKPISSL NRALSTVDIT SGEPATAINQ RSDVCAVPAA
360 370 380 390
GVVAEAMVAL VLAEAAVEKF GGDSVVEQRR NLAGYLDALV VR
Length:392
Mass (Da):41,154
Last modified:May 29, 2007 - v1
Checksum:i37562700E9E3D7C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP54307.1
RefSeqiWP_011905738.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP54307; ABP54307; Strop_1845
GeneIDi5058304
KEGGistp:Strop_1845
PATRICifig|369723.5.peg.1893

Similar proteinsi

Entry informationi

Entry nameiAROC_SALTO
AccessioniPrimary (citable) accession number: A4X607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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