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A4X4Z7 (A4X4Z7_SALTO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Strop_1481
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP] EMBL ABP53947.1
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116

Cofactor

Magnesium By similarity. HAMAP MF_00116

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region79 – 813Substrate binding By similarity HAMAP MF_00116
Region96 – 983Substrate binding By similarity HAMAP MF_00116

Sites

Binding site921Substrate By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
A4X4Z7 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: FD1CC2C3E7DD51BF

FASTA18118,351
        10         20         30         40         50         60 
MGRSPRNRME EGTVTDVVPV PVRQLDPGLP LPAYAHPGDA GADLVAAADV ELPPGGRALV 

        70         80         90        100        110        120 
PTGVAIALPE GYVGLVHPRS GLAARLGVTV LNAPGTVDAG YRGEILVNLI NHDRESAARI 

       130        140        150        160        170        180 
ARGDRIAQLV VQRVARARFQ PAAELPASQR GAGGHGSTGG HAGLGSAPAG TDGRQPVPEA 


S

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References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000667 Genomic DNA. Translation: ABP53947.1.
RefSeqYP_001158325.1. NC_009380.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4X4Z7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5057934.
GenomeReviewsGene locus Strop_1481 in contig CP000667_GR.
KEGGstp:Strop_1481.
PATRIC23441918. VBISalTro43511_1511.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHBG436079.
OMAKIAQMVI.
PhylomeDBA4X4Z7.
ProtClustDBCLSK969027.

Enzyme and pathway databases

BioCycSTRO369723:STROP_1481-MONOMER.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4X4Z7_SALTO
AccessionPrimary (citable) accession number: A4X4Z7
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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