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A4X4L7 (A4X4L7_SALTO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:Strop_1350
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP] EMBL ABP53817.1
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 3930NADP By similarity HAMAP MF_00183

Sites

Metal binding1621Divalent metal cation By similarity HAMAP MF_00183
Metal binding1641Divalent metal cation By similarity HAMAP MF_00183
Metal binding2331Divalent metal cation By similarity HAMAP MF_00183
Binding site1381Substrate By similarity HAMAP MF_00183
Binding site1641Substrate By similarity HAMAP MF_00183
Binding site1881Substrate By similarity HAMAP MF_00183
Binding site2111Substrate By similarity HAMAP MF_00183
Binding site2331Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A4X4L7 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: D9B585B558DB8CD4

FASTA40342,154
        10         20         30         40         50         60 
MTSPRDVVLL GSTGSIGTQA IDIVRRNPDR FRVVALGAGG GNVGLLAAQA LELGVEAVGV 

        70         80         90        100        110        120 
ARASAAQDLQ LAFYAEASRR GWARGEVRLP KIFAGPDAMT ELARWRSDVV LNGVVGSLGL 

       130        140        150        160        170        180 
APTLAALRAG RTLALANKES LVAGGPLVRA AVTRPGQIVP VDSEHTALAQ CLRSGSRAEV 

       190        200        210        220        230        240 
RRLLVTASGG PFRGRRRGEL TQVTPEQALA HPTWNMGPVV TINCATMVNK ALEVIEAHEL 

       250        260        270        280        290        300 
FDVPYADITV LVHPTSVIHS MVEFVDGSTI AQASPPDMRL PIALGLGWPD RVADAAPAVD 

       310        320        330        340        350        360 
WTTSHAWEFA PLDDAAFPAV ALAKAAGEAG CCRPAIYNAA NEECVAAFVA GRLPFLGIVD 

       370        380        390        400 
TVEQVLAEAP DFGEPGTVED VLAAESWARG HAQTIIEKSV EGA

« Hide

References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000667 Genomic DNA. Translation: ABP53817.1.
RefSeqYP_001158195.1. NC_009380.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4X4L7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5057803.
GenomeReviewsGene locus Strop_1350 in contig CP000667_GR.
KEGGstp:Strop_1350.
PATRIC23441648. VBISalTro43511_1376.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
HOGENOMHBG430762.
OMAIHSMVEY.
PhylomeDBA4X4L7.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycSTRO369723:STROP_1350-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4X4L7_SALTO
AccessionPrimary (citable) accession number: A4X4L7
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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