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Protein

Imidazolonepropionase

Gene

hutI

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

Cofactori

Zn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 1 zinc or iron ion per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (Strop_1106)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Zinc or ironUniRule annotation1
Metal bindingi71Zinc or ironUniRule annotation1
Binding sitei78SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Metal bindingi226Zinc or ironUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Metal bindingi302Zinc or ironUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00379; UER00551

Protein family/group databases

MEROPSiM38.980

Names & Taxonomyi

Protein namesi
Recommended name:
ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
Alternative name(s):
Imidazolone-5-propionate hydrolaseUniRule annotation
Gene namesi
Name:hutIUniRule annotation
Ordered Locus Names:Strop_1107
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000798271 – 392ImidazolonepropionaseAdd BLAST392

Interactioni

Protein-protein interaction databases

STRINGi369723.Strop_1107

Structurei

3D structure databases

ProteinModelPortaliA4X3X8
SMRiA4X3X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. HutI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI2 Bacteria
COG1228 LUCA
HOGENOMiHOG000218460
KOiK01468
OMAiCMMRAGT
OrthoDBiPOG091H0EIK

Family and domain databases

Gene3Di2.30.40.10, 2 hits
HAMAPiMF_00372 HutI, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR005920 HutI
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR42752 PTHR42752, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01224 hutI, 1 hit

Sequencei

Sequence statusi: Complete.

A4X3X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLLLDNIG ELVTNTAAGE GPLGIHRDAA VLVEDGVVAW VGPNGSAPAA
60 70 80 90 100
DRRIDAESAA VLPGFVDSHA HLVFAGDRAV EFAARMAGQP YTGGGIRTTV
110 120 130 140 150
GATRAATDDE LRATAHRLHA EALRQGTTTI EIKSGYGLTV VDEARSLRIA
160 170 180 190 200
AEVSSETTFL GAHLVPAEYA DRPDDYVDLV CGPMLAAAAP YARWVDVFCE
210 220 230 240 250
RGAFDADHTR AILTRGQAAG LGTRLHANQL GPGPGVQLGV ELGVASVDHC
260 270 280 290 300
THLTDADVDA LAGADGATVA TLLPGAEFST RSPYPDARRL LDAGVTVALA
310 320 330 340 350
TDCNPGSSYT SSVPFCIALA VREMRMSPSE AVWAATAGGA AALRRTDVGR
360 370 380 390
LAPGSQADLM ILDAPSHLHL AYRPGIPLIR QVLHNGVPQC RP
Length:392
Mass (Da):40,697
Last modified:May 29, 2007 - v1
Checksum:i00F7A26DA1AE0B18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP53578.1
RefSeqiWP_011905010.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP53578; ABP53578; Strop_1107
GeneIDi5057554
KEGGistp:Strop_1107
PATRICifig|369723.5.peg.1129

Similar proteinsi

Entry informationi

Entry nameiHUTI_SALTO
AccessioniPrimary (citable) accession number: A4X3X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: July 5, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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