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A4X3A6 (A4X3A6_SALTO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:Strop_0879
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP] EMBL ABP53356.1
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A4X3A6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 8DAA8521E0C5D1D9

FASTA32735,569
        10         20         30         40         50         60 
MSEAEAIRTG KRVILAKPRG YCAGVDRAVQ TVEEALKLYG APIYVRKQIV HNRHVVRTLE 

        70         80         90        100        110        120 
GKGAIFVEEN EEVPEGATVV FSAHGVAPEV HEQARSRSLK AIDATCPLVT KVHQEAKRFA 

       130        140        150        160        170        180 
AEDYDILLIG HEGHEEVIGT AGEAPEHIQL VDGPQDAERV TVRDPNKVVW LSQTTLSVDE 

       190        200        210        220        230        240 
TLETVARLKK RLPMLQSPPS DDICYATSNR QHVVKQIASD CDVMIVVGST NSSNSVRLVE 

       250        260        270        280        290        300 
VALDAGARAG HLVDFAREID DAWLEGARTV GLTSGASVPE ELVQEALAHL AARGFTDVEE 

       310        320 
VVTADERLTF SLPQELKRDM RAAAAHG

« Hide

References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000667 Genomic DNA. Translation: ABP53356.1.
RefSeqYP_001157734.1. NC_009380.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4X3A6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5057322.
GenomeReviewsGene locus Strop_0879 in contig CP000667_GR.
KEGGstp:Strop_0879.
PATRIC23440671. VBISalTro43511_0897.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAAMAPECD.
PhylomeDBA4X3A6.
ProtClustDBPRK01045.

Enzyme and pathway databases

BioCycSTRO369723:STROP_0879-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4X3A6_SALTO
AccessionPrimary (citable) accession number: A4X3A6
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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