A4X2N1 (A4X2N1_SALTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Quorum-sensing autoinducer 2 (AI-2), LuxS EMBL ABP53131.1

Gene names

Ordered Locus Names:

Strop_0654

Organism

Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP] EMBL ABP53131.1

Taxonomic identifier

369723 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. SAAS SAAS003815
Subunit structure	Homodimer By similarity. SAAS SAAS003815

Ontologies

Keywords
Biological process	Autoinducer synthesis SAAS SAAS003815 Quorum sensing SAAS SAAS003815
Ligand	Iron SAAS SAAS003815 Metal-binding SAAS SAAS003815
Molecular function	Lyase SAAS SAAS003815
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4X2N1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: C84FBBB951620FEE	FASTA	167	18,400
	10 20 30 40 50 60 MKQSHDLDHR HVVPPYLRIV NEQTVPGTSQ PVALWDFRVA QPNVSQVPGP VMHSLEHFLG 70 80 90 100 110 120 TYVRQHHSTI MNVGPMGCMT GLYVWTVGPW SFDDLAGVIA AGLRSIEDAD EVPLANVIQC 130 140 150 160 GWAEHHSLEG VKELAARLLA ERDQWGDPGP DAHEVSTADL RELSAGR

References

[1]

"Complete sequence of Salinispora tropica CNB-440." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000667 Genomic DNA. Translation: ABP53131.1.
RefSeq	YP_001157509.1. NC_009380.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4X2N1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5057095.
GenomeReviews	Gene locus Strop_0654 in contig CP000667_GR.
KEGG	stp:Strop_0654.
PATRIC	23440199. VBISalTro43511_0663.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1854.
HOGENOM	HBG347473.
OMA	PHGDTIT.
PhylomeDB	A4X2N1.
ProtClustDB	CLSK968694.
Enzyme and pathway databases
BioCyc	STRO369723:STROP_0654-MONOMER.
Family and domain databases
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4X2N1_SALTO

Accession

Primary (citable) accession number: A4X2N1

Entry history

Integrated into UniProtKB/TrEMBL:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)