Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei631D-inositol 3-phosphateUniRule annotation1
Binding sitei77UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei1321D-inositol 3-phosphateUniRule annotation1
Binding sitei1651D-inositol 3-phosphateUniRule annotation1
Binding sitei1891D-inositol 3-phosphateUniRule annotation1
Binding sitei2091D-inositol 3-phosphateUniRule annotation1
Binding sitei289UDP-GlcNAcUniRule annotation1
Binding sitei294UDP-GlcNAcUniRule annotation1
Binding sitei355UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi364Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi365Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi367Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei377UDP-GlcNAcUniRule annotation1
Binding sitei385UDP-GlcNAcUniRule annotation1
Metal bindingi391MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Strop_0331
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001561 – 482D-inositol 3-phosphate glycosyltransferaseAdd BLAST482

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi369723.Strop_0331.

Structurei

3D structure databases

ProteinModelPortaliA4X1R6.
SMRiA4X1R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 70UDP-GlcNAc bindingUniRule annotation2
Regioni74 – 791D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiView protein in InterPro
IPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
PfamiView protein in Pfam
PF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4X1R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNYRSPIGK MTPGVEVDRE APVVRAATVA EGADVAEQHT GVGHQRGARP
60 70 80 90 100
WPLPRRIATL SVHTSPLHQP GTGDAGGMNV YILEVARRLA EANVEVEIFT
110 120 130 140 150
RATAADLPPV VEMVPGVHVR HIMSGPLGGL TKEELPGQLC AFTAGVLRAE
160 170 180 190 200
AVRAAGHYDL IHSHYWLSGQ VGWLAKERWG VPLVHTAHTL AKVKNAQLAA
210 220 230 240 250
GDRPEPKARV IGEEQVVAEA DRLVANTKTE AGDLIDRYDA DPTRVEVVEP
260 270 280 290 300
GVDLARFCPA SGDRARAQVL ARRRLDLPER GYVVAFVGRI QPLKAPDVLI
310 320 330 340 350
RAAAALRQRD PALADDMTVV VCGGPSGSGL ERPTHLIELA AALGITDRVR
360 370 380 390 400
FLPPQTGDDL PALYRAADLV AVPSYNESFG LVALEAQACG TPVVAAAVGG
410 420 430 440 450
LNTAVRDEVS GVLVDGHDPV AWARSLGRLL PDAGRRAMLA RGAQRHARNF
460 470 480
SWDRTVKDLL DVYGEAVAEH RTRLSDFATC SR
Length:482
Mass (Da):51,686
Last modified:May 29, 2007 - v1
Checksum:iA20739447F3D9733
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA. Translation: ABP52816.1.

Genome annotation databases

EnsemblBacteriaiABP52816; ABP52816; Strop_0331.
KEGGistp:Strop_0331.

Similar proteinsi

Entry informationi

Entry nameiMSHA_SALTO
AccessioniPrimary (citable) accession number: A4X1R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: May 29, 2007
Last modified: September 27, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families