Skip Header

Contribute Send feedback
Read comments (?) or add your own

A4X169 (A4X169_SALTO) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Strop_0134
OrganismSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) [Complete proteome] [HAMAP] EMBL ABP52619.1
Taxonomic identifier369723 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora ›

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 303197ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding133 – 18452ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2731Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2751Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
A4X169 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 708D9D9E224119B4

FASTA41642,457
        10         20         30         40         50         60 
MRVLLIGSGG REHALALGLS ADPSVEVLFA APGNPGIGTV AVMRDVVFTD PAAVAALAVE 

        70         80         90        100        110        120 
CDADLVVVGP ETPLVAGVAD AVRAEGIPVF GPSAEAARLE GSKAFAKDVM TAARVPTARA 

       130        140        150        160        170        180 
YACADTESVG KALDDFGAPY VVKNDGLAAG KGVVVTEDRA AAEEHARECG QVVIEEYLAG 

       190        200        210        220        230        240 
PEVSLFVVTD GEAAVPLLPA QDFKRVGDGD TGPNTGGMGA YAPLPWAPPG LVDEVMRDIV 

       250        260        270        280        290        300 
HPTLAELRRR GTPFAGLLYV GLAITATGPR VIEFNARFGD PETQVVLALL ETPLAGLLHA 

       310        320        330        340        350        360 
AATGELAAHP PLRWRAGAAV TVVVAAQGYP AKPRTGDVIL GAERTGIVHA GTVRRAADGA 

       370        380        390        400        410 
LLSAGGRVLS VTATGSDLAA GRDAAYELVR GIELADSHHR TDIAAAAVEG RITIPR

« Hide

References

[1]"Complete sequence of Salinispora tropica CNB-440."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-916 / DSM 44818 / CNB-440.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000667 Genomic DNA. Translation: ABP52619.1.
RefSeqYP_001156997.1. NC_009380.1.

3D structure databases

ProteinModelPortalA4X169.
ModBaseSearch...

Protein-protein interaction databases

STRING369723.Strop_0134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP52619; ABP52619; Strop_0134.
GeneID5056567.
KEGGstp:Strop_0134.
PATRIC23439129. VBISalTro43511_0136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAMGAYTPL.
ProtClustDBPRK00885.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4X169_SALTO
AccessionPrimary (citable) accession number: A4X169
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info