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Protein

Ribulose bisphosphate carboxylase

Gene

cbbM

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111Substrate; in homodimeric partnerUniRule annotation1
Active sitei166Proton acceptorUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Metal bindingi191Magnesium; via carbamate groupUniRule annotation1
Metal bindingi193MagnesiumUniRule annotation1
Metal bindingi194MagnesiumUniRule annotation1
Active sitei287Proton acceptorUniRule annotation1
Binding sitei288SubstrateUniRule annotation1
Binding sitei321SubstrateUniRule annotation1
Sitei329Transition state stabilizerUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:cbbMUniRule annotation
Ordered Locus Names:Rsph17025_4020Imported
Encoded oniPlasmid pRSPA02Imported
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)Imported
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000000234 Componenti: Plasmid pRSPA02

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4WZQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 132RuBisCO_large_NInterPro annotationAdd BLAST121
Domaini142 – 440RuBisCO_largeInterPro annotationAdd BLAST299

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type II subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiTARRQYP.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08211. RuBisCO_large_II. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01339. RuBisCO_L_type2. 1 hit.
InterProiIPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020871. RuBisCO_lsuII.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WZQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNRYARL DLKEADLIAG GRHVLCAYVM KPKAGYGYLE TAAHFAAESS
60 70 80 90 100
TGTNVEVSTT DDFTRGVDAL VYEIDEAREL MKIAYPVELF DRNIIDGRAM
110 120 130 140 150
LCSFLTLTIG NNQGMGDVEY AKMHDFYVPP CYLRLFDGPS MNIADMWRVL
160 170 180 190 200
GRSVTDGGMV VGTIIKPKLG LRPKPFADAC YEFWLGGDFI KNDEPQGNQT
210 220 230 240 250
FAPLKETIRL VADAMKRAQD ETGEAKLFSA NITADDHYEM VARGEYILET
260 270 280 290 300
FGENADHVAF LVDGYVTGPA AITTARRQFP RQFLHYHRAG HGAVTSPQSM
310 320 330 340 350
RGYTAFVLSK MARLQGASGI HTGTMGFGKM EGEAADRIMA FMLTDDAAQG
360 370 380 390 400
PFYPQDWLGM KATTPIISGG MNALRLPGFF DNLGHSNVIQ TSGGGAFGHL
410 420 430 440 450
DGGTAGAKSL RQAHDAWKAG VDLVTYAREH RELARAFESF PADADRFHPG
460
WREKLQLAGA A
Length:461
Mass (Da):50,518
Last modified:May 29, 2007 - v1
Checksum:iE8F7E84A0EA6A01D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000663 Genomic DNA. Translation: ABP72873.1.
RefSeqiWP_011911067.1. NC_009430.1.

Genome annotation databases

EnsemblBacteriaiABP72873; ABP72873; Rsph17025_4020.
KEGGirsq:Rsph17025_4020.
PATRICi23166560. VBIRhoSph94549_4162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000663 Genomic DNA. Translation: ABP72873.1.
RefSeqiWP_011911067.1. NC_009430.1.

3D structure databases

ProteinModelPortaliA4WZQ9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP72873; ABP72873; Rsph17025_4020.
KEGGirsq:Rsph17025_4020.
PATRICi23166560. VBIRhoSph94549_4162.

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiTARRQYP.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08211. RuBisCO_large_II. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01339. RuBisCO_L_type2. 1 hit.
InterProiIPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020871. RuBisCO_lsuII.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4WZQ9_RHOS5
AccessioniPrimary (citable) accession number: A4WZQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits.UniRule annotation

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.