Skip Header

Contribute Send feedback
Read comments (?) or add your own

A4WZ47 (A4WZ47_RHOS5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412
Ordered Locus Names:Rsph17025_3804
Encoded onPlasmid pRSPA01 EMBL ABP72661.1
OrganismRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP]
Taxonomic identifier349102 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Sequences

Sequence LengthMass (Da)Tools
A4WZ47 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: B88F624EA99A1087

FASTA42044,402
        10         20         30         40         50         60 
MDGQDVTGLM QQIGARARAA AAELAFAEPE AKRQALLAAA DAVLVRQEEI LAANAEDLAF 

        70         80         90        100        110        120 
GTAKGLSPAM MDRLKLDAGR IGGVVEGLRA VAAQKDPVGE VIAEWDRPSG LHIRRVRTPL 

       130        140        150        160        170        180 
GVVGVIYESR PNVTADAGAL CLKSGNAVVL RGGSESFHTS TAIHACLQDG LRSAGLPEDA 

       190        200        210        220        230        240 
IQLVPTRDRA AVAEMLRMVE FIDVIVPRGG KGLVGLVQVE ARVPVFAHLE GICHVYADAD 

       250        260        270        280        290        300 
ADLEKARRVV LNAKTRRTGI CGAAECLLID RAFLAKHGPV LIEDLLKAGV EVRAEGELAQ 

       310        320        330        340        350        360 
VPGTVPAQPD DFGREFLDMI IAAKVVDGVD GAIAHIRRYG SSHTESILTE NDVTAGRFFQ 

       370        380        390        400        410        420 
RLDSAILMRN ASTQFADGGE FGMGAEIGIA TGKMHARGPV GAEQLTSFKY LVEGDGTIRP

« Hide

References

[1]"Complete sequence of plasmid pRSPA01 of Rhodobacter sphaeroides ATCC 17025."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17025 / ATH 2.4.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000662 Genomic DNA. Translation: ABP72661.1.
RefSeqYP_001169966.1. NC_009429.1.

3D structure databases

ProteinModelPortalA4WZ47.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4WZ47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5085345.
GenomeReviewsGene locus Rsph17025_3804 in contig CP000662_GR.
KEGGrsq:Rsph17025_3804.
PATRIC23166099. VBIRhoSph94549_3940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0014.
HOGENOMHBG318080.
OMAYGICGAM.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycRSPH349102:RSPH17025_3804-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4WZ47_RHOS5
AccessionPrimary (citable) accession number: A4WZ47
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info