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A4WXA5

- SYL_RHOS5

UniProt

A4WXA5 - SYL_RHOS5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei648 – 6481ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSPH349102:GHE1-4461-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rsph17025_3135
    OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
    Taxonomic identifieri349102 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000000234: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Leucine--tRNA ligasePRO_1000009415Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349102.Rsph17025_3135.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WXA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi645 – 6495"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4WXA5-1 [UniParc]FASTAAdd to Basket

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    MSRYDPAATE SRWQAAWDEA GVFTARHDPS RPKYYVLEMF PYPSGRIHMG    50
    HVRNYTMGDV VARQKAAAGY SVLHPMGWDA FGMPAENAAM ERGGHPKDWT 100
    YGNIADMRAQ MKPLGLSIDW SREFATCDPE YYGQQQAMFI DMLEAGLIYR 150
    KNAVVNWDPV DMTVLANEQV IDGKGWRSNA PVERRELTQW FFRISDYAGE 200
    LLEALDRLKD WPEKVRLMQA NWIGQSRGLQ FAFSTVNAPE GFDRLEVYTT 250
    RPDTLLGASF AAISPDHPLA KHLERHDAGV AEFVAECRRV GTSEEALEKA 300
    EKKGFDTGIR VRHPFDTALE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE 350
    FASKYGLPIP PVFVAEGTEE APLTEAFVPM KSERVAYVRG FAGAEIQTGE 400
    EAVAAAIDFC ESKGVGRGVT NYRLRDWGIS RQRYWGCPIP VIHCETCGVV 450
    PEAKENLPVR LPDDVTFDVP GNPLDRHPTW RDCTCPKCGA KARRETDTMD 500
    TFVDSSWYYA RFTAPRATTP TDPEEAEYWM NVDQYIGGIE HAILHLLYSR 550
    FFARAMQKTG HLPAKAIEPF NALFTQGMVT HEAYYSEEAK QEPVWQGMLE 600
    PGESPDTQMT VRHITYHFPE EVERTEDGAI LKTTGQKLKV IPSTKMSKSK 650
    KNVVDPMNII SQFGADTARW FVMSDSPPER DVEWTASGAE AAFKHLGRVW 700
    RLADEIARAE GAPTAEDVAL DRATAKAIAE VTQGIEGFAF NKAIAKLYEF 750
    TNTLSRSGAG AEAKRRAMRT MAQLMSPMVP HLAEEVWSML GGEGLVAQAP 800
    WPKADPALLV DDMVTLPIQI NGKRRAEVTV PKDMAASEVE KLVLADEAVQ 850
    RALSGGAPKK LIVVPGRIVN VVI 873
    Length:873
    Mass (Da):97,366
    Last modified:May 29, 2007 - v1
    Checksum:i9625CE7AD78EB108
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP72019.1.
    RefSeqiYP_001169324.1. NC_009428.1.

    Genome annotation databases

    EnsemblBacteriaiABP72019; ABP72019; Rsph17025_3135.
    GeneIDi5083087.
    KEGGirsq:Rsph17025_3135.
    PATRICi23164696. VBIRhoSph94549_3248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP72019.1 .
    RefSeqi YP_001169324.1. NC_009428.1.

    3D structure databases

    ProteinModelPortali A4WXA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349102.Rsph17025_3135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP72019 ; ABP72019 ; Rsph17025_3135 .
    GeneIDi 5083087.
    KEGGi rsq:Rsph17025_3135.
    PATRICi 23164696. VBIRhoSph94549_3248.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RSPH349102:GHE1-4461-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17025 / ATH 2.4.3.

    Entry informationi

    Entry nameiSYL_RHOS5
    AccessioniPrimary (citable) accession number: A4WXA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3