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A4WXA5

- SYL_RHOS5

UniProt

A4WXA5 - SYL_RHOS5

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Protein

Leucine--tRNA ligase

Gene
leuS, Rsph17025_3135
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei648 – 6481ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-4461-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Rsph17025_3135
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000000234: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Leucine--tRNA ligaseUniRule annotationPRO_1000009415Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349102.Rsph17025_3135.

Structurei

3D structure databases

ProteinModelPortaliA4WXA5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionUniRule annotationAdd
BLAST
Motifi645 – 6495"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WXA5-1 [UniParc]FASTAAdd to Basket

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MSRYDPAATE SRWQAAWDEA GVFTARHDPS RPKYYVLEMF PYPSGRIHMG    50
HVRNYTMGDV VARQKAAAGY SVLHPMGWDA FGMPAENAAM ERGGHPKDWT 100
YGNIADMRAQ MKPLGLSIDW SREFATCDPE YYGQQQAMFI DMLEAGLIYR 150
KNAVVNWDPV DMTVLANEQV IDGKGWRSNA PVERRELTQW FFRISDYAGE 200
LLEALDRLKD WPEKVRLMQA NWIGQSRGLQ FAFSTVNAPE GFDRLEVYTT 250
RPDTLLGASF AAISPDHPLA KHLERHDAGV AEFVAECRRV GTSEEALEKA 300
EKKGFDTGIR VRHPFDTALE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE 350
FASKYGLPIP PVFVAEGTEE APLTEAFVPM KSERVAYVRG FAGAEIQTGE 400
EAVAAAIDFC ESKGVGRGVT NYRLRDWGIS RQRYWGCPIP VIHCETCGVV 450
PEAKENLPVR LPDDVTFDVP GNPLDRHPTW RDCTCPKCGA KARRETDTMD 500
TFVDSSWYYA RFTAPRATTP TDPEEAEYWM NVDQYIGGIE HAILHLLYSR 550
FFARAMQKTG HLPAKAIEPF NALFTQGMVT HEAYYSEEAK QEPVWQGMLE 600
PGESPDTQMT VRHITYHFPE EVERTEDGAI LKTTGQKLKV IPSTKMSKSK 650
KNVVDPMNII SQFGADTARW FVMSDSPPER DVEWTASGAE AAFKHLGRVW 700
RLADEIARAE GAPTAEDVAL DRATAKAIAE VTQGIEGFAF NKAIAKLYEF 750
TNTLSRSGAG AEAKRRAMRT MAQLMSPMVP HLAEEVWSML GGEGLVAQAP 800
WPKADPALLV DDMVTLPIQI NGKRRAEVTV PKDMAASEVE KLVLADEAVQ 850
RALSGGAPKK LIVVPGRIVN VVI 873
Length:873
Mass (Da):97,366
Last modified:May 29, 2007 - v1
Checksum:i9625CE7AD78EB108
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP72019.1.
RefSeqiYP_001169324.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP72019; ABP72019; Rsph17025_3135.
GeneIDi5083087.
KEGGirsq:Rsph17025_3135.
PATRICi23164696. VBIRhoSph94549_3248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP72019.1 .
RefSeqi YP_001169324.1. NC_009428.1.

3D structure databases

ProteinModelPortali A4WXA5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349102.Rsph17025_3135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP72019 ; ABP72019 ; Rsph17025_3135 .
GeneIDi 5083087.
KEGGi rsq:Rsph17025_3135.
PATRICi 23164696. VBIRhoSph94549_3248.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RSPH349102:GHE1-4461-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17025 / ATH 2.4.3.

Entry informationi

Entry nameiSYL_RHOS5
AccessioniPrimary (citable) accession number: A4WXA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi