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A4WX36

- PUR5_RHOS5

UniProt

A4WX36 - PUR5_RHOS5

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-4392-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Rsph17025_3066
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000000234: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349102.Rsph17025_3066.

Structurei

3D structure databases

ProteinModelPortaliA4WX36.
SMRiA4WX36. Positions 7-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WX36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEQQKGLTY ADAGVDIDAG NALVERIKPA ARRTARPGTV SGLGGFGALF
60 70 80 90 100
DLKAAGYRDP VLVAATDGVG TKLRIAIDTG EVDTIGIDLV AMCVNDLVCQ
110 120 130 140 150
GAEPLFFLDY FATGKLELDQ AARIIEGIAE GCAASGCALI GGETAEMPGM
160 170 180 190 200
YHKGDFDLAG FAVGAMERGA DLPRGVAAGD VLLGLASNGV HSNGYSFVRK
210 220 230 240 250
VVELSGLAWD APSPFGGDSL GRALLAPTRL YVTQALAAVR AGGVHALAHI
260 270 280 290 300
TGGGLTENLP RVLPEGLGAR IDLGAWDLPP VFRWLAETAA MAEPELLKTF
310 320 330 340
NCGIGMIVVV AADRADAIAA LLEAEGETVT RIGEVIPGQG VSYDGRLL
Length:348
Mass (Da):35,815
Last modified:May 29, 2007 - v1
Checksum:iBDA5234A592FFC99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP71950.1.
RefSeqiWP_011910009.1. NC_009428.1.
YP_001169255.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP71950; ABP71950; Rsph17025_3066.
GeneIDi5085074.
KEGGirsq:Rsph17025_3066.
PATRICi23164556. VBIRhoSph94549_3178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP71950.1 .
RefSeqi WP_011910009.1. NC_009428.1.
YP_001169255.1. NC_009428.1.

3D structure databases

ProteinModelPortali A4WX36.
SMRi A4WX36. Positions 7-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349102.Rsph17025_3066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP71950 ; ABP71950 ; Rsph17025_3066 .
GeneIDi 5085074.
KEGGi rsq:Rsph17025_3066.
PATRICi 23164556. VBIRhoSph94549_3178.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci RSPH349102:GHE1-4392-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17025 / ATH 2.4.3.

Entry informationi

Entry nameiPUR5_RHOS5
AccessioniPrimary (citable) accession number: A4WX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3