UniProtKB - A4WWP0 (PNP_RHOS5)
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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Functioni
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation
Catalytic activityi
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 490 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 496 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-EC
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA catabolic process Source: InterPro
- RNA processing Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | RSPH349102:G1G8M-3014-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)Alternative name(s): Polynucleotide phosphorylaseUniRule annotation Short name: PNPaseUniRule annotation |
Gene namesi | Name:pnpUniRule annotation Ordered Locus Names:Rsph17025_2918 |
Organismi | Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) |
Taxonomic identifieri | 349102 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000329804 | 1 – 714 | Polyribonucleotide nucleotidyltransferaseAdd BLAST | 714 |
Structurei
3D structure databases
ProteinModelPortali | A4WWP0. |
SMRi | A4WWP0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 556 – 615 | KHUniRule annotationAdd BLAST | 60 | |
Domaini | 625 – 693 | S1 motifUniRule annotationAdd BLAST | 69 |
Sequence similaritiesi
Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C62. Bacteria. COG1185. LUCA. |
HOGENOMi | HOG000218326. |
KOi | K00962. |
OrthoDBi | POG091H00M0. |
Family and domain databases
Gene3Di | 3.30.1370.10. 1 hit. 3.30.230.70. 2 hits. |
HAMAPi | MF_01595. PNPase. 1 hit. |
InterProi | View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR036456. PNPase_PH_RNA-bd_sf. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain. |
PANTHERi | PTHR11252. PTHR11252. 1 hit. |
Pfami | View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit. |
PIRSFi | PIRSF005499. PNPase. 1 hit. |
SMARTi | View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit. |
SUPFAMi | SSF46915. SSF46915. 1 hit. SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits. |
TIGRFAMsi | TIGR03591. polynuc_phos. 1 hit. |
PROSITEi | View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit. |
i Sequence
Sequence statusi: Complete.
A4WWP0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNVTKKSIE WGGETLTLET GKVARQADGS VIATLGETSV MANVTFAKAA
60 70 80 90 100
KPGQDFFPLT VHYQERYYAA GKVPGGFFKR EARPSEKETL TSRLIDRPIR
110 120 130 140 150
PLFVDGFKNE VLLIVTVLSH DLVNEPDIVA MIAASAALTI SGVPFMGPIG
160 170 180 190 200
AARVGYANGE YVLNPDVDDM QKLRENPEQR LDLVIAGTKD AVMMVESEAY
210 220 230 240 250
ELSEAEMLGA VKFGHEAMQP VIDMIIDFAE EAAKEPFDFS PPDYAALYAK
260 270 280 290 300
VKSLGEAQMR AAFAIREKQE RVNAIDAARA AIKAQLSDAE LADENLGTAF
310 320 330 340 350
KKLESSILRG DIINGGARID GRDTKTVRPI ISETSVLPRT HGSALFTRGE
360 370 380 390 400
TQALVVTTLG TGEDEQIIDA LHGNSRSNFL LHYNFPPYSV GEVGRFGPPG
410 420 430 440 450
RREIGHGKLA WRALQAVLPA ATDFPYTIRV VSEITESNGS SSMASVCGGS
460 470 480 490 500
LSMMDAGVPL KAPVAGVAMG LILEDDGKWA VLTDILGDED HLGDMDFKVA
510 520 530 540 550
GTENGITSLQ MDIKVAGITP AIMEQALAQA KDGRMHILGE MSKALSSANS
560 570 580 590 600
FSAYAPKIET LTIPTDKIRE VIGSGGKVIR EIVETSGAKV DINDDGVIKI
610 620 630 640 650
ASNDQAAIKK AYDMIWSIVA EPEEGQIYTG KVVKLVDFGA FVNFFGKRDG
660 670 680 690 700
LVHVSQIANK RLTHPNEVLK EGQEVKVKLL GFDERGKVRL GMKMVDQETG
710
QEIAPEKKEE ATEA
Sequence cautioni
The sequence ABP71804 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000661 Genomic DNA. Translation: ABP71804.1. Different initiation. |
RefSeqi | WP_044248416.1. NC_009428.1. |
Genome annotation databases
EnsemblBacteriai | ABP71804; ABP71804; Rsph17025_2918. |
KEGGi | rsq:Rsph17025_2918. |
Similar proteinsi
Entry informationi
Entry namei | PNP_RHOS5 | |
Accessioni | A4WWP0Primary (citable) accession number: A4WWP0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | April 29, 2008 | |
Last modified: | February 28, 2018 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |