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A4WVV8 (A4WVV8_RHOS5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Rsph17025_2635
OrganismRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP]
Taxonomic identifier349102 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2441Iron By similarity HAMAP MF_00323
Metal binding3251Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A4WVV8 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: D386B4E4F1C4CFF7

FASTA37742,703
        10         20         30         40         50         60 
MYGSGMTPML QATPEQARTL GAEEPIHPGE DRLTHAPADH PDLPQPKIGI LLANLGTPDN 

        70         80         90        100        110        120 
YDYWSMRRYL NEFLSDKRVI DYPAWKWQPL LQILILSKRP FSSGANYKLI WNHDKGESPL 

       130        140        150        160        170        180 
MTITRDQTAR IAAEMRALHG NRVIVDFCMR YGNPSTESRV RAMVDAGCEK ILFFPLYPHY 

       190        200        210        220        230        240 
AGATSATAND QFFRAMMKEK RQPAVRTAPE YYAHPLYIDA LARSVERAYA DLDHRPDVLV 

       250        260        270        280        290        300 
ASYHGMPKRY LLAGDPYHCQ CAKTSRLLRE RLGWDKDAID TTFQSVFGPE EWLKPYTVEH 

       310        320        330        340        350        360 
VAELARAGKK RIAVIAPAFS ADCIETLEEI NGEIREAFEE AGGEEFTYIP CLNDDEAHIK 

       370 
ALVAVIEENL AGWVGRD

« Hide

References

[1]"Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17025 / ATH 2.4.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000661 Genomic DNA. Translation: ABP71522.1.
RefSeqYP_001168827.1. NC_009428.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4WVV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5085059.
GenomeReviewsGene locus Rsph17025_2635 in contig CP000661_GR.
KEGGrsq:Rsph17025_2635.
PATRIC23163615. VBIRhoSph94549_2721.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBA4WVV8.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycRSPH349102:RSPH17025_2635-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4WVV8_RHOS5
AccessionPrimary (citable) accession number: A4WVV8
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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