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A4WV42 (A4WV42_RHOS5) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:Rsph17025_2367 EMBL ABP71256.1
OrganismRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP] EMBL ABP71256.1
Taxonomic identifier349102 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding308 – 3136NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A4WV42 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 57DCEDD585FC6DBC

FASTA40445,271
        10         20         30         40         50         60 
MSKIKVANPV VELDGDEMTR IIWDFIKQKL ILPYLDIDLH YYDLGIEERD RTEDQITVDA 

        70         80         90        100        110        120 
ANAIKQYGVG VKCATITPDE ARVEEFGLKQ MWKSPNGTIR NILGGVIFRQ PIICKNVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV GRHAFGDQYR ATDFRFPGKG KLTLKFVGED GTVIEREVFD APGAGVTMAM 

       190        200        210        220        230        240 
YNLDESILDF ARASMNYGLN LGWPVYLSTK NTILKAYDGR FKDLFQKVYE EEFADRFKAA 

       250        260        270        280        290        300 
GITYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQAG KETSTNSIAS IFAWTGGLKH RAKLDDNAEL MRFAETLERV 

       370        380        390        400 
TVQAVEDGFM TKDLALLVGP DQKWLTTMGY LEKVDEYLDR ALGA 

« Hide

References

[1]"Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17025 / ATH 2.4.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000661 Genomic DNA. Translation: ABP71256.1.
RefSeqYP_001168561.1. NC_009428.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349102.Rsph17025_2367.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP71256; ABP71256; Rsph17025_2367.
GeneID5083860.
KEGGrsq:Rsph17025_2367.
PATRIC23163059. VBIRhoSph94549_2445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAKELSFFA.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycRSPH349102:GHE1-3694-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4WV42_RHOS5
AccessionPrimary (citable) accession number: A4WV42
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 13, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)