ID   BETB_RHOS5              Reviewed;         483 AA.
AC   A4WUY6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   16-JUN-2009, entry version 15.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=Rsph17025_2311;
OS   Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=349102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.,
RA   Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome of Rhodobacter sphaeroides ATCC
RT   17025.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000661; ABP71200.1; -; Genomic_DNA.
DR   RefSeq; YP_001168505.1; -.
DR   GeneID; 5084961; -.
DR   GenomeReviews; CP000661_GR; Rsph17025_2311.
DR   KEGG; rsq:Rsph17025_2311; -.
DR   OMA; A4WUY6; HEATPAV.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR011264; Betaine_Ald_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    483       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_1000047056.
FT   NP_BIND     227    232       NAD (By similarity).
FT   ACT_SITE    249    249       By similarity.
FT   ACT_SITE    283    283       By similarity.
SQ   SEQUENCE   483 AA;  50779 MW;  03FB2EE7057CE106 CRC64;
     MRAQPAASHF VDGRPLEDAA GAPIPVIHPA NGEEIARLHE ATPAVIEAAL ASGARAQKDW
     AALRPVERAR ILRRASDLIR ARNEELSILE TLDTGKPLQE TLVADWPSGA DALEFFAGLA
     PAVTGETVPL GQDFVYTIRE PLGLCVGIGA WNYPSQIACW KAAPALALGN AMVFKPSEVT
     PLGALKLAEI LIEAGLPPGL FNVVQGRGAV GAALVSDSRV AKVSLTGSVP TGRRVYAAAA
     EGVRHVTMEL GGKSPLIVFD DADLESAIGA AMLGNFYSSG QICSNGTRVF VQKGIKEAFL
     ARLAERADAI QMGDPLDPEV QMGPLVSPAQ LEKVLSYIEK ARAEGGRLVC GGEASVSPGC
     YVQPTVFADV TDGMTLAREE VFGPVMAVLD FETEEEVIAR ANATDFGLAA GVFTADLTRA
     HRVVAQLQAG TCWINAYNLT PVEAPFGGVK MSGVGRENGR AAVEHYTQVK SVYVGMGPVD
     APY
//