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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Potassium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei161Charge relay systemUniRule annotation1
Metal bindingi179Potassium 1; via carbonyl oxygenUniRule annotation1
Binding sitei208NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi243Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei249Proton acceptorUniRule annotation1
Binding sitei283NAD/NADPUniRule annotation1
Binding sitei380NAD/NADPUniRule annotation1
Metal bindingi450Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi453Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei457Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 152NAD/NADPUniRule annotation4
Nucleotide bindingi175 – 178NAD/NADPUniRule annotation4
Nucleotide bindingi227 – 232NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:Rsph17025_2311
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000000234 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000470561 – 483NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi349102.Rsph17025_2311.

Structurei

3D structure databases

ProteinModelPortaliA4WUY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271505.
KOiK00130.
OMAiEYTQVKH.
OrthoDBiPOG091H05FS.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WUY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQPAASHF VDGRPLEDAA GAPIPVIHPA NGEEIARLHE ATPAVIEAAL
60 70 80 90 100
ASGARAQKDW AALRPVERAR ILRRASDLIR ARNEELSILE TLDTGKPLQE
110 120 130 140 150
TLVADWPSGA DALEFFAGLA PAVTGETVPL GQDFVYTIRE PLGLCVGIGA
160 170 180 190 200
WNYPSQIACW KAAPALALGN AMVFKPSEVT PLGALKLAEI LIEAGLPPGL
210 220 230 240 250
FNVVQGRGAV GAALVSDSRV AKVSLTGSVP TGRRVYAAAA EGVRHVTMEL
260 270 280 290 300
GGKSPLIVFD DADLESAIGA AMLGNFYSSG QICSNGTRVF VQKGIKEAFL
310 320 330 340 350
ARLAERADAI QMGDPLDPEV QMGPLVSPAQ LEKVLSYIEK ARAEGGRLVC
360 370 380 390 400
GGEASVSPGC YVQPTVFADV TDGMTLAREE VFGPVMAVLD FETEEEVIAR
410 420 430 440 450
ANATDFGLAA GVFTADLTRA HRVVAQLQAG TCWINAYNLT PVEAPFGGVK
460 470 480
MSGVGRENGR AAVEHYTQVK SVYVGMGPVD APY
Length:483
Mass (Da):50,779
Last modified:May 29, 2007 - v1
Checksum:i03FB2EE7057CE106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP71200.1.
RefSeqiWP_011909271.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP71200; ABP71200; Rsph17025_2311.
KEGGirsq:Rsph17025_2311.
PATRICi23162939. VBIRhoSph94549_2385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP71200.1.
RefSeqiWP_011909271.1. NC_009428.1.

3D structure databases

ProteinModelPortaliA4WUY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349102.Rsph17025_2311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP71200; ABP71200; Rsph17025_2311.
KEGGirsq:Rsph17025_2311.
PATRICi23162939. VBIRhoSph94549_2385.

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271505.
KOiK00130.
OMAiEYTQVKH.
OrthoDBiPOG091H05FS.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBETB_RHOS5
AccessioniPrimary (citable) accession number: A4WUY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.