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A4WUY6

- BETB_RHOS5

UniProt

A4WUY6 - BETB_RHOS5

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, Rsph17025_2311
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei161 – 1611Charge relay system By similarity
Metal bindingi179 – 1791Potassium 1; via carbonyl oxygen By similarity
Binding sitei208 – 2081NAD/NADP; via amide nitrogen By similarity
Metal bindingi243 – 2431Potassium 2; via carbonyl oxygen By similarity
Active sitei249 – 2491Proton acceptor By similarity
Binding sitei283 – 2831NAD/NADP By similarity
Binding sitei380 – 3801NAD/NADP By similarity
Metal bindingi450 – 4501Potassium 2; via carbonyl oxygen By similarity
Metal bindingi453 – 4531Potassium 2; via carbonyl oxygen By similarity
Active sitei457 – 4571Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1524NAD/NADP By similarity
Nucleotide bindingi175 – 1784NAD/NADP By similarity
Nucleotide bindingi227 – 2326NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-3638-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Rsph17025_2311
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000000234: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000047056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi349102.Rsph17025_2311.

Structurei

3D structure databases

ProteinModelPortaliA4WUY6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCEHQLVA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WUY6-1 [UniParc]FASTAAdd to Basket

« Hide

MRAQPAASHF VDGRPLEDAA GAPIPVIHPA NGEEIARLHE ATPAVIEAAL    50
ASGARAQKDW AALRPVERAR ILRRASDLIR ARNEELSILE TLDTGKPLQE 100
TLVADWPSGA DALEFFAGLA PAVTGETVPL GQDFVYTIRE PLGLCVGIGA 150
WNYPSQIACW KAAPALALGN AMVFKPSEVT PLGALKLAEI LIEAGLPPGL 200
FNVVQGRGAV GAALVSDSRV AKVSLTGSVP TGRRVYAAAA EGVRHVTMEL 250
GGKSPLIVFD DADLESAIGA AMLGNFYSSG QICSNGTRVF VQKGIKEAFL 300
ARLAERADAI QMGDPLDPEV QMGPLVSPAQ LEKVLSYIEK ARAEGGRLVC 350
GGEASVSPGC YVQPTVFADV TDGMTLAREE VFGPVMAVLD FETEEEVIAR 400
ANATDFGLAA GVFTADLTRA HRVVAQLQAG TCWINAYNLT PVEAPFGGVK 450
MSGVGRENGR AAVEHYTQVK SVYVGMGPVD APY 483
Length:483
Mass (Da):50,779
Last modified:May 29, 2007 - v1
Checksum:i03FB2EE7057CE106
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP71200.1.
RefSeqiWP_011909271.1. NC_009428.1.
YP_001168505.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP71200; ABP71200; Rsph17025_2311.
GeneIDi5084961.
KEGGirsq:Rsph17025_2311.
PATRICi23162939. VBIRhoSph94549_2385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP71200.1 .
RefSeqi WP_011909271.1. NC_009428.1.
YP_001168505.1. NC_009428.1.

3D structure databases

ProteinModelPortali A4WUY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349102.Rsph17025_2311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP71200 ; ABP71200 ; Rsph17025_2311 .
GeneIDi 5084961.
KEGGi rsq:Rsph17025_2311.
PATRICi 23162939. VBIRhoSph94549_2385.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CEHQLVA.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci RSPH349102:GHE1-3638-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17025 / ATH 2.4.3.

Entry informationi

Entry nameiBETB_RHOS5
AccessioniPrimary (citable) accession number: A4WUY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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