Reviewed, UniProtKB/Swiss-Prot A4WUY6 (BETB_RHOS5)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Rsph17025_2311

Organism

Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP]

Taxonomic identifier

349102 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Betaine aldehyde dehydrogenase		PRO_1000047056
Regions
	Nucleotide binding	227 – 232	6	NAD By similarity
Sites
	Active site	249	1	By similarity
	Active site	283	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4WUY6-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 03FB2EE7057CE106	FASTA	483	50,779
	10 20 30 40 50 60 MRAQPAASHF VDGRPLEDAA GAPIPVIHPA NGEEIARLHE ATPAVIEAAL ASGARAQKDW 70 80 90 100 110 120 AALRPVERAR ILRRASDLIR ARNEELSILE TLDTGKPLQE TLVADWPSGA DALEFFAGLA 130 140 150 160 170 180 PAVTGETVPL GQDFVYTIRE PLGLCVGIGA WNYPSQIACW KAAPALALGN AMVFKPSEVT 190 200 210 220 230 240 PLGALKLAEI LIEAGLPPGL FNVVQGRGAV GAALVSDSRV AKVSLTGSVP TGRRVYAAAA 250 260 270 280 290 300 EGVRHVTMEL GGKSPLIVFD DADLESAIGA AMLGNFYSSG QICSNGTRVF VQKGIKEAFL 310 320 330 340 350 360 ARLAERADAI QMGDPLDPEV QMGPLVSPAQ LEKVLSYIEK ARAEGGRLVC GGEASVSPGC 370 380 390 400 410 420 YVQPTVFADV TDGMTLAREE VFGPVMAVLD FETEEEVIAR ANATDFGLAA GVFTADLTRA 430 440 450 460 470 480 HRVVAQLQAG TCWINAYNLT PVEAPFGGVK MSGVGRENGR AAVEHYTQVK SVYVGMGPVD APY

References

[1]

"Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000661 Genomic DNA. Translation: ABP71200.1.
RefSeq	YP_001168505.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5084961.
GenomeReviews	Gene locus Rsph17025_2311 in contig CP000661_GR.
KEGG	rsq:Rsph17025_2311.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_RHOS5

Accession

Primary (citable) accession number: A4WUY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 29, 2007
Last modified:	November 4, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)