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A4WUX2 (GCSP_RHOS5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Rsph17025_2297
OrganismRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP]
Taxonomic identifier349102 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045603

Amino acid modifications

Modified residue6971N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4WUX2 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: AE93CC7DEC3410D3

FASTA956103,186
        10         20         30         40         50         60 
MTFTPTDYNA YDFANRRHIG PSPSEMEEML RVVGVSSLDQ LIEETVPASI RQDQPLDWAP 

        70         80         90        100        110        120 
LAEHELLQKM REVAAKNRVM VSLIGQGYYG TVTPPAIQRN ILENPAWYTA YTPYQPEIAQ 

       130        140        150        160        170        180 
GRLEALLNYQ TMVADLTGLP VANASLLDEA TAAAEAMTMA ERASKSKARA FFVDADCHPQ 

       190        200        210        220        230        240 
TIAVIRTRAE PLGIEVIVGH PAQLVPEDVF GALFQYPGTY GLVRDFTREI AALHEAKALA 

       250        260        270        280        290        300 
IVATDLLALC LLKEPGAMGA DIAIGSSQRF GVPMGYGGPH AAFMSCRDEL KRSMPGRLVG 

       310        320        330        340        350        360 
VSVDARGNKA YRLALQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG PKGLRHIAER 

       370        380        390        400        410        420 
VHLNTVRLAQ ALKEAGARVS PEAFFDTITV EVGVGQAGIL AAARHRGINL RKVGRDRVGI 

       430        440        450        460        470        480 
SLDETTDAGV IARVLDAFGI HDPAPASVGL GFPEAMLRES AYLSHPVFDM NRAESEMMRY 

       490        500        510        520        530        540 
MRRLSDRDLA LDRAMIPLGS CTMKLNAAAE MMPITWPEFA TLHPFAPPEQ AAGYTEAIRD 

       550        560        570        580        590        600 
LSDRLCRITG YDAMSMQPNS GAQGEYAGLL TILAYHRARG EGQRTICLIP MSAHGTNPAS 

       610        620        630        640        650        660 
AQMAGMKVVV VKSAPNGDVD LDDFRDKAAA AGDRLAACMI TYPSTHGVFE ETVRDVCRIT 

       670        680        690        700        710        720 
HEHGGQVYID GANMNAMVGL VQPGAIGGDV SHLNLHKTFA IPHGGGGPGM GPIGVKAHLA 

       730        740        750        760        770        780 
PYLPGHPETG GPLAGGQIVA THEGPVSAAP YGSASILLIS WAYCLMMGGE GLTQATRVAI 

       790        800        810        820        830        840 
LNANYVAARL RGAYDVLFMG NRGRVAHECI LDTRPFAEAG VTVDDIAKRL IDNGFHAPTM 

       850        860        870        880        890        900 
SWPVPGTLMV EPTESETKAE IDRFITALLA IREEIRAVEA GEIAAADSPL RHAPHTVEDL 

       910        920        930        940        950 
VADWDRNYPR EQGCFPPGAF RVDKYWPPVG RVDNAWGDRN LVCICPPVES YSIAAQ 

« Hide

References

[1]"Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17025 / ATH 2.4.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000661 Genomic DNA. Translation: ABP71186.1.
RefSeqYP_001168491.1. NC_009428.1.

3D structure databases

ProteinModelPortalA4WUX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349102.Rsph17025_2297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP71186; ABP71186; Rsph17025_2297.
GeneID5083716.
KEGGrsq:Rsph17025_2297.
PATRIC23162907. VBIRhoSph94549_2369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycRSPH349102:GHE1-3624-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHOS5
AccessionPrimary (citable) accession number: A4WUX2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families