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A4WUX2

- GCSP_RHOS5

UniProt

A4WUX2 - GCSP_RHOS5

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRSPH349102:GHE1-3624-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Rsph17025_2297
    OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
    Taxonomic identifieri349102 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000000234: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 956956Glycine dehydrogenase (decarboxylating)PRO_1000045603Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei697 – 6971N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi349102.Rsph17025_2297.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WUX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4WUX2-1 [UniParc]FASTAAdd to Basket

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    MTFTPTDYNA YDFANRRHIG PSPSEMEEML RVVGVSSLDQ LIEETVPASI    50
    RQDQPLDWAP LAEHELLQKM REVAAKNRVM VSLIGQGYYG TVTPPAIQRN 100
    ILENPAWYTA YTPYQPEIAQ GRLEALLNYQ TMVADLTGLP VANASLLDEA 150
    TAAAEAMTMA ERASKSKARA FFVDADCHPQ TIAVIRTRAE PLGIEVIVGH 200
    PAQLVPEDVF GALFQYPGTY GLVRDFTREI AALHEAKALA IVATDLLALC 250
    LLKEPGAMGA DIAIGSSQRF GVPMGYGGPH AAFMSCRDEL KRSMPGRLVG 300
    VSVDARGNKA YRLALQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG 350
    PKGLRHIAER VHLNTVRLAQ ALKEAGARVS PEAFFDTITV EVGVGQAGIL 400
    AAARHRGINL RKVGRDRVGI SLDETTDAGV IARVLDAFGI HDPAPASVGL 450
    GFPEAMLRES AYLSHPVFDM NRAESEMMRY MRRLSDRDLA LDRAMIPLGS 500
    CTMKLNAAAE MMPITWPEFA TLHPFAPPEQ AAGYTEAIRD LSDRLCRITG 550
    YDAMSMQPNS GAQGEYAGLL TILAYHRARG EGQRTICLIP MSAHGTNPAS 600
    AQMAGMKVVV VKSAPNGDVD LDDFRDKAAA AGDRLAACMI TYPSTHGVFE 650
    ETVRDVCRIT HEHGGQVYID GANMNAMVGL VQPGAIGGDV SHLNLHKTFA 700
    IPHGGGGPGM GPIGVKAHLA PYLPGHPETG GPLAGGQIVA THEGPVSAAP 750
    YGSASILLIS WAYCLMMGGE GLTQATRVAI LNANYVAARL RGAYDVLFMG 800
    NRGRVAHECI LDTRPFAEAG VTVDDIAKRL IDNGFHAPTM SWPVPGTLMV 850
    EPTESETKAE IDRFITALLA IREEIRAVEA GEIAAADSPL RHAPHTVEDL 900
    VADWDRNYPR EQGCFPPGAF RVDKYWPPVG RVDNAWGDRN LVCICPPVES 950
    YSIAAQ 956
    Length:956
    Mass (Da):103,186
    Last modified:May 29, 2007 - v1
    Checksum:iAE93CC7DEC3410D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP71186.1.
    RefSeqiYP_001168491.1. NC_009428.1.

    Genome annotation databases

    EnsemblBacteriaiABP71186; ABP71186; Rsph17025_2297.
    GeneIDi5083716.
    KEGGirsq:Rsph17025_2297.
    PATRICi23162907. VBIRhoSph94549_2369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP71186.1 .
    RefSeqi YP_001168491.1. NC_009428.1.

    3D structure databases

    ProteinModelPortali A4WUX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349102.Rsph17025_2297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP71186 ; ABP71186 ; Rsph17025_2297 .
    GeneIDi 5083716.
    KEGGi rsq:Rsph17025_2297.
    PATRICi 23162907. VBIRhoSph94549_2369.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RSPH349102:GHE1-3624-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17025 / ATH 2.4.3.

    Entry informationi

    Entry nameiGCSP_RHOS5
    AccessioniPrimary (citable) accession number: A4WUX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3