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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-3177-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Rsph17025_1850
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000000234 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_1000015259Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349102.Rsph17025_1850.

Structurei

3D structure databases

ProteinModelPortaliA4WTM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiPOG091H00ZG.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WTM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSDFDFDL PERLIATRPA RPRTAARLLL AEGDRIEDRH VRDLVGIFHP
60 70 80 90 100
GDRLVLNNTR VIPARLVGTR TRGEACAKIE ITLMEPAAAG GWRALAKPLR
110 120 130 140 150
KLKEGETIRF SDALSAEVAE KGETDLRLVF DRAGEDFDAA LAEAGAMPLP
160 170 180 190 200
PYIAARRAPD AQDREDYQTV FARHAGAVAA PTASLHFDRP LLEALAANGV
210 220 230 240 250
AFTEVTLHVG AGTFLPVKVE DVTTHRMHAE WGEVTEAAAA EIAATKAAGG
260 270 280 290 300
RVIPVGTTAL RLIESASAAG TIRPWRGETD IFIYPGYRFR VTDALMTNFH
310 320 330 340
LPKSTLLMLV SALMGEARIR AIYDHAVRHD YRFFSYGDAS LLIPGG
Length:346
Mass (Da):37,699
Last modified:May 29, 2007 - v1
Checksum:iA360342798E3E98A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP70741.1.
RefSeqiWP_011908863.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP70741; ABP70741; Rsph17025_1850.
KEGGirsq:Rsph17025_1850.
PATRICi23161988. VBIRhoSph94549_1915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP70741.1.
RefSeqiWP_011908863.1. NC_009428.1.

3D structure databases

ProteinModelPortaliA4WTM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349102.Rsph17025_1850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP70741; ABP70741; Rsph17025_1850.
KEGGirsq:Rsph17025_1850.
PATRICi23161988. VBIRhoSph94549_1915.

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiPOG091H00ZG.

Enzyme and pathway databases

UniPathwayiUPA00392.
BioCyciRSPH349102:GHE1-3177-MONOMER.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEA_RHOS5
AccessioniPrimary (citable) accession number: A4WTM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.