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A4WSW3

- A4WSW3_RHOS5

UniProt

A4WSW3 - A4WSW3_RHOS5

Protein

Kynureninase

Gene

kynU

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei90 – 901Pyridoxal phosphateUniRule annotation
    Binding sitei158 – 1581Pyridoxal phosphateUniRule annotation
    Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
    Binding sitei190 – 1901Pyridoxal phosphateUniRule annotation
    Binding sitei212 – 2121Pyridoxal phosphateUniRule annotation
    Binding sitei242 – 2421Pyridoxal phosphateUniRule annotation
    Binding sitei268 – 2681Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciRSPH349102:GHE1-2911-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Rsph17025_1584Imported
    OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)Imported
    Taxonomic identifieri349102 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000000234: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei213 – 2131N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349102.Rsph17025_1584.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WSW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1204Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiVWDLAHS.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4WSW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGAMTDFEA TRAMFDLPEG VIYLDGNSLG PLPRAAAARV AACVTEEWGG    50
    MLVTGWNRAG WMEMPRRLGD RIGRLVGAEP GTVVLGDTLS IKVFQALAAA 100
    CEMRPGRRVI LSDSGNFPSD LYMAEGLCRM LGDRELRLVA PEEVEGAITD 150
    ELAAVMVTEV DYRTGRRHDM AAITAKAHAA GALAIWDLAH SAGALPVRVA 200
    EDGADFAVGC TYKYLNSGPG GPAFIYVAPR HGERAVPALS GWLGHAAPFA 250
    FDLAYRPGRG VERMRVGTPP VIQMAALDAA LDVWDGVDLA RLRTRSLELT 300
    DLFIAEVETR CPELALATPR DHARRGSQVS FRHPEGYPIM QALIARGVIG 350
    DFRAPDILRF GFTPLYIGPA EVVRAAAILS EVMEGRLWDR EDYRQRAAVT 400
    Length:400
    Mass (Da):43,329
    Last modified:May 29, 2007 - v1
    Checksum:iB76C43921F6DC989
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP70477.1.
    RefSeqiWP_011908606.1. NC_009428.1.
    YP_001167782.1. NC_009428.1.

    Genome annotation databases

    EnsemblBacteriaiABP70477; ABP70477; Rsph17025_1584.
    GeneIDi5082395.
    KEGGirsq:Rsph17025_1584.
    PATRICi23161418. VBIRhoSph94549_1633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP70477.1 .
    RefSeqi WP_011908606.1. NC_009428.1.
    YP_001167782.1. NC_009428.1.

    3D structure databases

    ProteinModelPortali A4WSW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349102.Rsph17025_1584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP70477 ; ABP70477 ; Rsph17025_1584 .
    GeneIDi 5082395.
    KEGGi rsq:Rsph17025_1584.
    PATRICi 23161418. VBIRhoSph94549_1633.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi VWDLAHS.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci RSPH349102:GHE1-2911-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17025 / ATH 2.4.3Imported.

    Entry informationi

    Entry nameiA4WSW3_RHOS5
    AccessioniPrimary (citable) accession number: A4WSW3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3