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A4WSQ8 (AROB_RHOS5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Rsph17025_1528
OrganismRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP]
Taxonomic identifier349102 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3703703-dehydroquinate synthase HAMAP MF_00110
PRO_1000094589

Sequences

Sequence LengthMass (Da)Tools
A4WSQ8 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 2DA7C9B5D02F3D43

FASTA37039,495
        10         20         30         40         50         60 
MTVDAVRVEL GARAYEVRIG PGLIARAGAE IAPLLRRPKL AILTDETVAG LHLAPFQAAL 

        70         80         90        100        110        120 
AEAGIASSAL ALPAGEATKG WEQFSRAVEW LLEEKVERRD VVVALGGGVI GDLAGFAAAV 

       130        140        150        160        170        180 
LRRGVRFVQV PTTLLAQVDS SVGGKTGINT AQGKNLVGAF HQPSLVLADI GVLESLPARD 

       190        200        210        220        230        240 
FLAGYGEVVK YGLLGDADFF EWLEGAAPRL ASDPEARQRA VRRSVEMKAE IVARDETEEG 

       250        260        270        280        290        300 
DRALLNLGHT FCHALEKATG YSDRLLHGEG VAIGCALAFE LSQHMGLCPQ EAPSRLRAHL 

       310        320        330        340        350        360 
RAMGMKVDLR DIPGDLPDAE GLLRLMAQDK KVVDGKLRFI LARDIGAAFV AKDVPGDLVR 

       370 
RILQEALATR

« Hide

References

[1]"Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17025 / ATH 2.4.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000661 Genomic DNA. Translation: ABP70422.1.
RefSeqYP_001167727.1. NC_009428.1.

3D structure databases

ProteinModelPortalA4WSQ8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4WSQ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5084252.
GenomeReviewsGene locus Rsph17025_1528 in contig CP000661_GR.
KEGGrsq:Rsph17025_1528.
PATRIC23161298. VBIRhoSph94549_1573.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBA4WSQ8.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycRSPH349102:RSPH17025_1528-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_RHOS5
AccessionPrimary (citable) accession number: A4WSQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 29, 2007
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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