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A4WQ81

- GCH4_RHOS5

UniProt

A4WQ81 - GCH4_RHOS5

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei218 – 2181May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciRSPH349102:GHE1-1968-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Rsph17025_0639
    OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
    Taxonomic identifieri349102 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000000234: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359GTP cyclohydrolase FolE2PRO_1000068669Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349102.Rsph17025_0639.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WQ81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4WQ81-1 [UniParc]FASTAAdd to Basket

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    MNILTPVADR LPSREEAEEA LAVLRRWAKH TPVSDVAGLA PDVPALVYPE    50
    FSRSYPRNFT VDEAYKASLP DLQNGPASLI VGAKAVIQHV GISNFRLPIR 100
    YHTRDNGDLT LETSVTGTVS LEAEKKGINM SRIMRSFYAH AEQGFSFEVI 150
    ERALEDYKRD LESFDARIQM RFSFPVKVPS LRSGLVGWQY YDIALELVDR 200
    GGVRKKIMHL DFVYSSTCPC SLELSEHARR ERGQLATPHS QRSVARISVE 250
    VRPGKCLWFE DLIELARAAV PTETQVMVKR EDEQAFAELN AANPIFVEDA 300
    ARSFCQALQA DPRIGDFRVV ASHQESLHSH DAVSVLTEGP TFAAESLDPR 350
    LFASLYHTG 359
    Length:359
    Mass (Da):40,159
    Last modified:May 29, 2007 - v1
    Checksum:i8B3657134040B156
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP69545.1.
    RefSeqiYP_001166850.1. NC_009428.1.

    Genome annotation databases

    EnsemblBacteriaiABP69545; ABP69545; Rsph17025_0639.
    GeneIDi5082983.
    KEGGirsq:Rsph17025_0639.
    PATRICi23159419. VBIRhoSph94549_0648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP69545.1 .
    RefSeqi YP_001166850.1. NC_009428.1.

    3D structure databases

    ProteinModelPortali A4WQ81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349102.Rsph17025_0639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP69545 ; ABP69545 ; Rsph17025_0639 .
    GeneIDi 5082983.
    KEGGi rsq:Rsph17025_0639.
    PATRICi 23159419. VBIRhoSph94549_0648.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci RSPH349102:GHE1-1968-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17025 / ATH 2.4.3.

    Entry informationi

    Entry nameiGCH4_RHOS5
    AccessioniPrimary (citable) accession number: A4WQ81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3