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A4WQ81

- GCH4_RHOS5

UniProt

A4WQ81 - GCH4_RHOS5

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Rsph17025_0639
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei218 – 2181May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-1968-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Rsph17025_0639
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000000234: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359GTP cyclohydrolase FolE2UniRule annotationPRO_1000068669Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349102.Rsph17025_0639.

Structurei

3D structure databases

ProteinModelPortaliA4WQ81.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WQ81-1 [UniParc]FASTAAdd to Basket

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MNILTPVADR LPSREEAEEA LAVLRRWAKH TPVSDVAGLA PDVPALVYPE    50
FSRSYPRNFT VDEAYKASLP DLQNGPASLI VGAKAVIQHV GISNFRLPIR 100
YHTRDNGDLT LETSVTGTVS LEAEKKGINM SRIMRSFYAH AEQGFSFEVI 150
ERALEDYKRD LESFDARIQM RFSFPVKVPS LRSGLVGWQY YDIALELVDR 200
GGVRKKIMHL DFVYSSTCPC SLELSEHARR ERGQLATPHS QRSVARISVE 250
VRPGKCLWFE DLIELARAAV PTETQVMVKR EDEQAFAELN AANPIFVEDA 300
ARSFCQALQA DPRIGDFRVV ASHQESLHSH DAVSVLTEGP TFAAESLDPR 350
LFASLYHTG 359
Length:359
Mass (Da):40,159
Last modified:May 29, 2007 - v1
Checksum:i8B3657134040B156
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP69545.1.
RefSeqiYP_001166850.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP69545; ABP69545; Rsph17025_0639.
GeneIDi5082983.
KEGGirsq:Rsph17025_0639.
PATRICi23159419. VBIRhoSph94549_0648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP69545.1 .
RefSeqi YP_001166850.1. NC_009428.1.

3D structure databases

ProteinModelPortali A4WQ81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349102.Rsph17025_0639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP69545 ; ABP69545 ; Rsph17025_0639 .
GeneIDi 5082983.
KEGGi rsq:Rsph17025_0639.
PATRICi 23159419. VBIRhoSph94549_0648.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci RSPH349102:GHE1-1968-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17025 / ATH 2.4.3.

Entry informationi

Entry nameiGCH4_RHOS5
AccessioniPrimary (citable) accession number: A4WQ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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