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A4WQ11

- FTHS_RHOS5

UniProt

A4WQ11 - FTHS_RHOS5

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-1898-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Rsph17025_0569
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000000234: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_1000068791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349102.Rsph17025_0569.

Structurei

3D structure databases

ProteinModelPortaliA4WQ11.
SMRiA4WQ11. Positions 6-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WQ11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFQSDIEIA RAANKLPIQE IGARLGIPSG DLIPYGHDKA KVSQGFIRGL
60 70 80 90 100
ADRPDGKLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKR AVICIREASL
110 120 130 140 150
GPNFGMKGGA AGGGRSQVVP MEDMNLHFTG DFHAITSAHN LLSAMIDNHI
160 170 180 190 200
YWGNDLGLDA RRITWRRVMD MNDRALRDMV VNLGGVSNGF PRQTGFDITV
210 220 230 240 250
ASEVMAILCL AEDLEDLERR LGGIVVGYRR DRSPVFCRDL KADGAMAVLL
260 270 280 290 300
KDAMQPNLVQ TIENNPAFVH GGPFANIAHG CNSVIATRTA LKLADYVVTE
310 320 330 340 350
AGFGADLGAE KFFDIKCRKA GLKPSAAVVV ATVRALKMNG GVAREDLGRE
360 370 380 390 400
DVAALKRGCA NLGRHIANVK GFGVPVVVAI NHFTTDTEAE IEAVRAYAAG
410 420 430 440 450
QGAEAILCRH WADGSAGIED LARKVVQLAE TPSMFAPLYP DEMPLFEKME
460 470 480 490 500
TVARRIYHAH DVIADHVIRD QLRAWEDAGY GALPVCMAKT QYSFTTDAAI
510 520 530 540 550
RGAPEGHSVP IREVRLSAGA GFVVAICGEI RTMPGLPREP AAEVIRLNGE

GRIEGLF
Length:557
Mass (Da):59,748
Last modified:May 29, 2007 - v1
Checksum:iC4CD3642735EADAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP69475.1.
RefSeqiYP_001166780.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP69475; ABP69475; Rsph17025_0569.
GeneIDi5082874.
KEGGirsq:Rsph17025_0569.
PATRICi23159271. VBIRhoSph94549_0576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP69475.1 .
RefSeqi YP_001166780.1. NC_009428.1.

3D structure databases

ProteinModelPortali A4WQ11.
SMRi A4WQ11. Positions 6-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349102.Rsph17025_0569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP69475 ; ABP69475 ; Rsph17025_0569 .
GeneIDi 5082874.
KEGGi rsq:Rsph17025_0569.
PATRICi 23159271. VBIRhoSph94549_0576.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RSPH349102:GHE1-1898-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17025 / ATH 2.4.3.

Entry informationi

Entry nameiFTHS_RHOS5
AccessioniPrimary (citable) accession number: A4WQ11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3