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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.UniRule annotation

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.UniRule annotation

Pathwayi: pyrroloquinoline quinone biosynthesis

This protein is involved in the pathway pyrroloquinoline quinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pyrroloquinoline quinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-1717-MONOMER.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthaseUniRule annotation (EC:1.3.3.11UniRule annotation)
Alternative name(s):
Coenzyme PQQ synthesis protein CUniRule annotation
Pyrroloquinoline quinone biosynthesis protein CUniRule annotation
Gene namesi
Name:pqqCUniRule annotation
Ordered Locus Names:Rsph17025_0388
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000000234 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Pyrroloquinoline-quinone synthasePRO_1000061679Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349102.Rsph17025_0388.

Structurei

3D structure databases

ProteinModelPortaliA4WPI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiPOG091H0KR9.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WPI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDLTPTLS PARPLDSADA MEDRLREIGA ARYHDRHPFH HLLHGGQLTR
60 70 80 90 100
GQVQAWALNR YYYQCSIPVK DAVVISRFRD RATRVEWRHR LEDHDGAEGT
110 120 130 140 150
EGGIDRWLVL TDALGLDRDY VEATDGILPA TRFAVDAYVH FVRDQSPLEA
160 170 180 190 200
IASCLTELFA PHIHAERISG MLAHYDFVNP TVMAYFQRRL SQAPRDADYA
210 220 230 240 250
LRYVREHART PQERAAVCNA LIFKTQVLWT QLDALHHAYV LGHVPPGAFV

PEDMR
Length:255
Mass (Da):29,089
Last modified:May 29, 2007 - v1
Checksum:iE789A491EC3D8435
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP69294.1.
RefSeqiWP_011907447.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP69294; ABP69294; Rsph17025_0388.
KEGGirsq:Rsph17025_0388.
PATRICi23158896. VBIRhoSph94549_0391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA. Translation: ABP69294.1.
RefSeqiWP_011907447.1. NC_009428.1.

3D structure databases

ProteinModelPortaliA4WPI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349102.Rsph17025_0388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP69294; ABP69294; Rsph17025_0388.
KEGGirsq:Rsph17025_0388.
PATRICi23158896. VBIRhoSph94549_0391.

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiPOG091H0KR9.

Enzyme and pathway databases

UniPathwayiUPA00539.
BioCyciRSPH349102:GHE1-1717-MONOMER.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPQQC_RHOS5
AccessioniPrimary (citable) accession number: A4WPI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.